Dimenhidrinat: Perbedaan antara revisi
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←Membuat halaman berisi ''''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati mabuk gerak dan mual. Dimenhidrinat adalah garam teoklat yang terdiri dari difenhidramin (turunan etanolamina) dan 8-kloroteofilin (turunan teofilin terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Se...' Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
Tidak ada ringkasan suntingan Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
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{{Infobox drug |
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| Verifiedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = 459441657 |
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| type = combo |
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| image = Dimenhydrinate.svg |
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| width = 160 |
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| alt = |
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| caption = |
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<!-- Combo data --> |
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| component1 = Difenhidramin |
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| class1 = [[Antihistamin]], [[sedatif]] |
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| component2 = 8-kloroteofilin |
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| class2 = [[Stimulan]] |
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| tradename = Antimo, dramamine, Draminate, Gravol, dll |
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| Drugs.com = {{drugs.com|monograph|dimenhydrinate}} |
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| MedlinePlus = a607046 |
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| DailyMedID = Dimenhydrinate |
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| pregnancy_AU = A |
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| pregnancy_AU_comment = |
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| pregnancy_category = |
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| routes_of_administration = [[Oral (rute pemberian obat)|Oral]], [[rektal]], [[intravaskular]], [[Penyuntikan intraotot|intramuskular]] |
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| ATCvet = |
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| ATC_prefix = R06 |
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| ATC_suffix = AA11 |
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| ATC_supplemental = combinations {{ATC|R06|AA61}} |
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<!-- Pharmacokinetic data --> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = [[Liver]] |
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| elimination_half-life = 5.5 hours<ref name="oral_sublingual2328304">{{cite journal | vauthors = Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ | title = Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration | journal = Biopharmaceutics & Drug Disposition | volume = 11 | issue = 3 | pages = 185–189 | date = April 1990 | pmid = 2328304 | doi = 10.1002/bdd.2510110302 }}</ref> (diphenhydramine component) |
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| excretion = |
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<!-- Legal status --> |
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| legal_AU = S2 |
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| legal_AU_comment = |
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| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> |
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| legal_BR_comment = |
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| legal_CA = [[Over-the-counter drug|OTC]] |
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| legal_CA_comment = |
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| legal_DE = <!-- Anlage I, II, III or Unscheduled --> |
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| legal_DE_comment = |
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| legal_NZ = <!-- Class A, B, C --> |
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| legal_NZ_comment = |
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| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> |
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| legal_UK_comment = |
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| legal_US = OTC |
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| legal_US_comment = |
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| legal_EU = |
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| legal_EU_comment = |
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| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> |
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| legal_UN_comment = |
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| legal_status = <!-- For countries not listed above --> |
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<!-- Identifiers --> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 523-87-5 |
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| CAS_supplemental = |
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| PubChem = 10660 |
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| IUPHAR_ligand = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB00985 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 10210 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = JB937PER5C |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D00520 |
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| ChEBI = 94848 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 1200406 |
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| NIAID_ChemDB = |
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| PDB_ligand = |
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| synonyms = |
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}} |
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'''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati [[mabuk gerak]] dan [[mual]]. Dimenhidrinat adalah garam teoklat yang terdiri dari [[difenhidramin]] (turunan [[etanolamina]]) dan 8-kloroteofilin (turunan [[teofilin]] terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Second |chapter=34 - Pharmacology of Postoperative Nausea and Vomiting |publisher=[[Elsevier Inc.]] |year=2019 |isbn=978-0-323-48110-6 | veditors = Hemmings Jr HC, Talmage ED |pages=671–692 |doi=10.1016/B978-0-323-48110-6.00034-X |s2cid=81387334 | vauthors = Zabirowicz ES, Gan TJ }}</ref> Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.<ref name="Newman 2012">{{cite web | vauthors = Newman A |title=New Dramamine Ads Take Aim at Summer Vacationers |website=The New York Times |date=21 June 2012 |url=https://www.nytimes.com/2012/06/21/business/media/new-dramamine-ads-take-aim-at-summer-vacationers.html |access-date=26 June 2023}}</ref><ref name="Grauer 2019">{{cite web | vauthors = Grauer N |title=Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness |website=Johns Hopkins Medicine |date=12 February 2019 |url=https://www.hopkinsmedicine.org/news/articles/hopkins-history-moments-3 |access-date=27 June 2023}}</ref> |
'''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati [[mabuk gerak]] dan [[mual]]. Dimenhidrinat adalah garam teoklat yang terdiri dari [[difenhidramin]] (turunan [[etanolamina]]) dan 8-kloroteofilin (turunan [[teofilin]] terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Second |chapter=34 - Pharmacology of Postoperative Nausea and Vomiting |publisher=[[Elsevier Inc.]] |year=2019 |isbn=978-0-323-48110-6 | veditors = Hemmings Jr HC, Talmage ED |pages=671–692 |doi=10.1016/B978-0-323-48110-6.00034-X |s2cid=81387334 | vauthors = Zabirowicz ES, Gan TJ }}</ref> Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.<ref name="Newman 2012">{{cite web | vauthors = Newman A |title=New Dramamine Ads Take Aim at Summer Vacationers |website=The New York Times |date=21 June 2012 |url=https://www.nytimes.com/2012/06/21/business/media/new-dramamine-ads-take-aim-at-summer-vacationers.html |access-date=26 June 2023}}</ref><ref name="Grauer 2019">{{cite web | vauthors = Grauer N |title=Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness |website=Johns Hopkins Medicine |date=12 February 2019 |url=https://www.hopkinsmedicine.org/news/articles/hopkins-history-moments-3 |access-date=27 June 2023}}</ref> |
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Revisi per 22 Mei 2024 22.34
Kombinasi | |
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Difenhidramin | Antihistamin, sedatif |
8-kloroteofilin | Stimulan |
Data klinis | |
Nama dagang | Antimo, dramamine, Draminate, Gravol, dll |
AHFS/Drugs.com | monograph |
MedlinePlus | a607046 |
Data lisensi | US Daily Med:pranala |
Kat. kehamilan | A(AU) |
Status hukum | Apotek saja (S2) (AU) ? (CA) OTC (US) |
Rute | Oral, rektal, intravaskular, intramuskular |
Pengenal | |
Nomor CAS | 523-87-5 |
Kode ATC | R06AA11 combinations R06AA61 |
PubChem | CID 10660 |
DrugBank | DB00985 |
ChemSpider | 10210 |
UNII | JB937PER5C |
KEGG | D00520 |
ChEBI | CHEBI:94848 |
ChEMBL | CHEMBL1200406 |
Dimenhidrinat merupakan obat bebas yang digunakan untuk mengobati mabuk gerak dan mual. Dimenhidrinat adalah garam teoklat yang terdiri dari difenhidramin (turunan etanolamina) dan 8-kloroteofilin (turunan teofilin terklorinasi) dengan perbandingan 1:1.[1] Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.[2][3]
Referensi
- ^ Zabirowicz ES, Gan TJ (2019). "34 - Pharmacology of Postoperative Nausea and Vomiting". Dalam Hemmings Jr HC, Talmage ED. Pharmacology and Physiology for Anesthesia (edisi ke-Second). Elsevier Inc. hlm. 671–692. doi:10.1016/B978-0-323-48110-6.00034-X. ISBN 978-0-323-48110-6.
- ^ Newman A (21 June 2012). "New Dramamine Ads Take Aim at Summer Vacationers". The New York Times. Diakses tanggal 26 June 2023.
- ^ Grauer N (12 February 2019). "Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness". Johns Hopkins Medicine. Diakses tanggal 27 June 2023.