Lihat sumber Plumbagin

{{chembox
|   Name = Plumbagin
|   ImageFile = Plumbagin.PNG
|   IUPACName = 5-hidroksi-2-metil-naftalena-1,4-dion
|   OtherNames = 
| Section1 = {{Chembox Identifiers
|   CASNo = 481-42-5
|   SMILES = CC1=CC(=O)C2=C(C1=O)C=CC=C2O
  }}
| Section2 = {{Chembox Properties
|   Formula = C<sub>11</sub>H<sub>8</sub>O<sub>3</sub>
|   MolarMass = 188,17942 g/mol
|   Density = 
|   MeltingPt = 
|   BoilingPt = 
|   Solubility = 
  }}
}}

'''Plumbagin''' (5-Hidroksi-2-metil-1,4-naftokuinon) merupakan senyawa [[naftokuinon]] yang diturunkan dari tumbuh-tumbuhan dan memiliki berbagai aktivitas farmakologis. Telah ditemukan bahwa ia memiliki aktivitas [[mikroorganisme|antimikroba]].<ref>Didry, N., L. Dubrevil & M. Pinkas 1994. Activity of anthraquinonic and naphthoquinonic compounds on oral bacteria. ''Die Pharmazie'' '''49'''(9): 681–683.</ref><ref>Paiva, S.R.d., M.R. Figueiredo, T. V. Aragão, M.A.C. Kaplan 2003. {{PDFlink|[http://www.scielo.br/pdf/mioc/v98n7/v98n7a17.pdf Antimicrobial Activity in Vitro of Plumbagin Isolated from ''Plumbago'' Species.]|511&nbsp;[[Kibibyte|KiB]]<!-- application/pdf, 523331 bytes -->}} ''Mem Inst Oswaldo Cruz'' '''98'''(7): 959–961.</ref> Pada hewan, ia memiliki efek [[malaria|antimalaria]],<ref>Likhitwitayawuid, K., R. Kaewamatawong, N. Ruangrungsi & J. Krungkrai 1998. Antimalarial naphthoquinones from ''Nepenthes thorelii''. ''Planta Medica'' '''64'''(3): 237–241.</ref> [[karsinogen|antikanker]],<ref>Parimala, R. & P. Sachdanandam 1993. Effect of plumbagin on some glucose metabolizing enzymes studied in rats in experimental hepatoma. ''Molecular and Cellular Biochemistry'' '''12'''(1): 59–63.</ref><ref>Hsu, Y.-L., C.-Y. Cho, P.-L. Kuo, Y.-T. Huang & C.-C. Lin 2006. Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo. ''Journal of Pharmacology and Experimental Therapeutics'' '''318'''(2): 484–494. {{DOI|10.1124/jpet.105.098863}}</ref> [[jantung|kardiotonik]],<ref>Itoigawa, M., K. Takeya & H. Furukawa 1991. Cardiotonic action of plumbagin on guinea-pig [[papillary muscle]]. ''Planta Medica'' '''57'''(4): 317–319.</ref> [[fertelitas|anti kesuburan]],<ref>Bhargava, S.K. 1984. Effects of plumbagin on reproductive function of male dog. ''Indian Journal of Experimental Biology'' '''22'''(3): 153–156.</ref> dan [[aterosklerosis|anti-aterosklerosis]].<ref>Ding, Y., Z.-J. Chen, S. Liu, D. Che, M. Vetter, C.-H. Chang 2005. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. ''Journal of Pharmacy and Pharmacology'' '''57'''(1): 111.</ref>

Nama plumbagin berasal dari genus tumbuhan ''[[Plumbago]]'', yang darinya ia pertama kali diisolasi<ref>Van der Vijver, L.M. 1972. Distribution of plumbagin in the Plumbaginaceae. ''Phytochemistry'' '''11''': 3247–3248.</ref>

== Referensi ==
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