Lihat sumber Benzonatat

{{Infobox drug|drug_name=|image=Benzonatate.svg|width=250px|alt=|caption=|type=<!-- empty -->

<!-- Names -->|tradename=Tessalon, Zonatuss, others|synonyms=|IUPAC_name=2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-(butylamino)benzoate

<!-- Clinical data -->|pregnancy_AU=<!-- A / B1 / B2 / B3 / C / D / X -->|pregnancy_US=C|pregnancy_category=|routes_of_administration=By mouth|dependency_liability=|Drugs.com={{drugs.com|monograph|benzonatate}}|MedlinePlus=a682640

<!-- Legal data -->|legal_AU=<!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->|legal_CA=<!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->|legal_UK=<!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->|legal_US=Rx-only|legal_status=<!--For countries not listed above-->|DailyMedID=Benzonatate|licence_US=<!-- FDA may use generic or brand name (generic name preferred) -->|licence_EU=<!-- EMA uses INN (or special INN_EMA) -->

<!-- Pharmacokinetic data -->|bioavailability=|protein_bound=|metabolism=|elimination_half-life=3-8 hours|excretion=<!-- Chemical and physical data -->|C=30|H=53|N=1|O=11|chemical_formula=|smiles=O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)c1ccc(NCCCC)cc1|StdInChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChI_comment=|StdInChIKey=MAFMQEKGGFWBAB-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|density=|melting_point=|melting_high=|melting_notes=|boiling_point=|boiling_notes=|solubility=|specific_rotation=}}

'''Benzonatat''' atau Benzonatate adalah obat yang digunakan untuk membantu menurunkan gejala dari [[batuk]] dan [[cegukan]] . <ref name="AHFS2019">{{Cite web|title=Benzonatate Monograph for Professionals|url=https://www.drugs.com/monograph/benzonatate.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html|archive-date=28 December 2021|access-date=23 March 2019|url-status=live}}</ref> <ref name="Bec2010">{{Cite journal|last=Becker|first=DE|date=2010|title=Nausea, vomiting, and hiccups: a review of mechanisms and treatment.|journal=Anesthesia Progress|volume=57|issue=4|pages=150–6; quiz 157|doi=10.2344/0003-3006-57.4.150|pmc=3006663|pmid=21174569}}</ref> Rute pemberian obat melalui oral. <ref name="AHFS2019">{{cite web |title=Benzonatate Monograph for Professionals |url=https://www.drugs.com/monograph/benzonatate.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=23 March 2019 |archive-date=28 December 2021 |archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html |url-status=live }}</ref> Penggunaan obat tidak direkomendasikan anak yang  berusia di bawah 10 tahun. <ref name="ML2018">{{Cite journal|date=17 December 2018|title=Drugs for cough.|journal=The Medical Letter on Drugs and Therapeutics|volume=60|issue=1562|pages=206–208|pmid=30625123}}</ref> Efek terapi muncul memerlukan waktu kurang lebih 20 menit dan akan bertahan hingga 8 jam. <ref name="AHFS2019">{{cite web |title=Benzonatate Monograph for Professionals |url=https://www.drugs.com/monograph/benzonatate.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=23 March 2019 |archive-date=28 December 2021 |archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html |url-status=live }}</ref> <ref name="PI2021">{{Cite web|last=|first=|date=20 November 2019|title=Tessalon - benzonatate capsule|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8edd07a0-5f5b-9000-bafb-dbf8ff7609d4|website=DailyMed|archive-url=https://web.archive.org/web/20211107100900/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8edd07a0-5f5b-9000-bafb-dbf8ff7609d4|archive-date=7 November 2021|access-date=21 April 2020|url-status=live}}</ref>

Kejadian efek samping yang umum terjadi pada penggunaan obat ini yakni  rasa mengantuk, ras pusing, sakit kepala, sakit perut, ruam kulit, [[halusinasi]], dan [[Alergi|timbul reaksi alergi]] . <ref name="AHFS2019">{{Cite web|title=Benzonatate Monograph for Professionals|url=https://www.drugs.com/monograph/benzonatate.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html|archive-date=28 December 2021|access-date=23 March 2019|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/benzonatate.html "Benzonatate Monograph for Professionals"]. ''Drugs.com''. American Society of Health-System Pharmacists. [https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html Archived] from the original on 28 December 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">23 March</span> 2019</span>.</cite></ref> Penggunaan dosis yang berlebih bisa menyebabkan [[Sawan|kejang]], [[Aritmia|detak jantung tidak teratur]], hingga kematian. <ref name="ML2018">{{Cite journal|date=17 December 2018|title=Drugs for cough.|journal=The Medical Letter on Drugs and Therapeutics|volume=60|issue=1562|pages=206–208|pmid=30625123}}<cite class="citation journal cs1" data-ve-ignore="true">"Drugs for cough". ''The Medical Letter on Drugs and Therapeutics''. '''60''' (1562): 206–208. 17 December 2018. [[PubMed|PMID]]&nbsp;[https://pubmed.ncbi.nlm.nih.gov/30625123 30625123].</cite></ref> Jika menghisap ataupun mengunyah  sediaan kapsul obat ini bisa menyebabkan [[laringospasme]], bronkospasme, dan [[syok]] . <ref name="AHFS2019">{{cite web |title=Benzonatate Monograph for Professionals |url=https://www.drugs.com/monograph/benzonatate.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=23 March 2019 |archive-date=28 December 2021 |archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html |url-status=live }}</ref> Belum diketahui secara pasti apakah obat ini aman untuk ibu [[Kehamilan|hamil]] atau ibu[[menyusui]] . <ref name="Preg2020">{{Cite web|date=10 October 2019|title=Benzonatate Use During Pregnancy|url=https://www.drugs.com/pregnancy/benzonatate.html|website=Drugs.com|archive-url=https://web.archive.org/web/20211108073032/https://www.drugs.com/pregnancy/benzonatate.html|archive-date=8 November 2021|access-date=20 February 2020|url-status=live}}</ref> Mekanisme kerja obat ini yakni dengan menghentikan reseptor regangan di paru-paru dan menekan refleks batuk di otak. <ref name="AHFS2019">{{cite web |title=Benzonatate Monograph for Professionals |url=https://www.drugs.com/monograph/benzonatate.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=23 March 2019 |archive-date=28 December 2021 |archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html |url-status=live }}</ref>

== Referensi ==

[[Kategori:Obat]]
[[Kategori:Farmasi]]