Lihat sumber Antidepresan

{{Infobox drug class
| Image= File:Venlafaxine structure.svg
| Alt= 225px
| Caption= 
| Pronounce=
| Synonyms=
<!-- Class identifiers -->
| Use=Gangguan depresi
| ATC_prefix=N06A
| Mode_of_action=
| Mechanism_of_action=
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| Chemical_class=
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| Drugs.com={{Drugs.com|drug-class|antidepressants}}
| MedlinePlus=antidepressants
| Consumer_Reports= antidepressants
| medicinenet= antidepressants
| rxlist=100734
<!-- Pranala luar -->
| MeshID=D000928
}}

'''Antidepresan''' adalah sebuah [[obat]] yang digunakan untuk mengobati [[gangguan depresi mayor]], beberapa [[gangguan kecemasan]], beberapa kondisi [[nyeri kronis]], dan untuk membantu mengelola beberapa [[kecanduan]].<ref name="Jennings2018">{{cite book|title=Clinical psychopharmacology for neurologists: a practical guide|last1=Jennings|first1=Leigh|date=2018|publisher=Springer|isbn=978-3-319-74602-9|editor1-last=Grossberg|editor1-first=George T.|pages=45–71|chapter=Chapter 4: Antidepressants|doi=10.1007/978-3-319-74604-3_4|editor2-last=Kinsella|editor2-first=Laurence J.}}</ref> [[Efek samping]] umum dari antidepresan termasuk [[Xerostomia|mulut kering]], [[penambahan berat badan]], [[pusing]], [[sakit kepala]], dan [[disfungsi seksual]].<ref>{{cite journal | vauthors = Healy D, Noury LJ, Manginb D | title = Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases | journal = International Journal of Risk & Safety in Medicine | volume = 29 | issue = 3 | pages = 125–134 | date = May 2018 | pmid = 29733030 | pmc = 6004900 | doi = 10.3233/JRS-180744 }}</ref><ref name="Bahrick">{{cite journal |doi=10.2174/1874350100801010042 |title=Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence |journal=The Open Psychology Journal |volume=1 |pages=42–50 |year=2008 |last1=Bahrick |first1=Audrey S. | name-list-format = vanc }}</ref><ref>{{cite journal | vauthors = Taylor MJ, Rudkin L, Bullemor-Day P, Lubin J, Chukwujekwu C, Hawton K | title = Strategies for managing sexual dysfunction induced by antidepressant medication | journal = The Cochrane Database of Systematic Reviews | volume = 5 | issue = 5 | pages = CD003382 | date = May 2013 | pmid = 23728643 | doi = 10.1002/14651858.CD003382.pub3 | url = https://kclpure.kcl.ac.uk/portal/en/publications/strategies-for-managing-sexual-dysfunction-induced-by-antidepressant-medication(5f0f0033-e139-42cc-9590-d3b5cad1bb25).html }}</ref><ref>{{cite journal | vauthors = Kennedy SH, Rizvi S | title = Sexual dysfunction, depression, and the impact of antidepressants | journal = Journal of Clinical Psychopharmacology | volume = 29 | issue = 2 | pages = 157–64 | date = April 2009 | pmid = 19512977 | doi = 10.1097/jcp.0b013e31819c76e9 }}</ref><ref>[https://www.ema.europa.eu/en/documents/other/new-product-information-wording-extracts-prac-recommendations-signals-adopted-13-16-may-2019-prac_en.pdf Serotonin and noradrenaline reuptake inhibitors (SNRI); selective serotonin reuptake inhibitors (SSRI) – Persistent sexual dysfunction after drug withdrawal ](EPITT no 19277), 11 June 20191, EMA/PRAC/265221/2019, Pharmacovigilance Risk Assessment Committee (PRAC)</ref>

Sebagian besar jenis antidepresan biasanya aman dikonsumsi, tetapi dapat menyebabkan meningkatnya pikiran untuk bunuh diri ketika dikonsumsi oleh anak-anak, remaja, dan dewasa muda. Sindrom penghentian dapat terjadi setelah menghentikan antidepresan yang menyerupai depresi berulang.

== Jenis ==
Berikut merupakan jenis obat antidepresan:
===''Selective Serotonin Re-uptake Inhibitor'' (SSRIs)===
* [[Citalopram]] 
* [[Escitalopram]] 
* [[Fluoksetin]] 
* [[Fluvoksamin]] 
* [[Paroksetin]] 
* [[Sertralin]] 

;Dihentikan/ditarik
* [[Indalpin]] 
* [[Zimelidin]] 

===''Serotonin and Norepinephrine Reuptake Inhibitors'' (SNRIs)===
* [[Desvenlafaksin]] 
* [[Duloksetin]] 
* [[Levomilnacipran]] 
* [[Milnacipran]] 
* [[Venlafaksin]]

===''Serotonin–norepinephrine–dopamine reuptake inhibitors'' (SNDRIs)===
* [[Toludesvenlafaksin]]
* [[Nefazodon]]<ref name="Tatsumi1997">{{cite journal | vauthors = Tatsumi M, Groshan K, Blakely RD, Richelson E | title = Pharmacological profile of antidepressants and related compounds at human monoamine transporters | journal = European Journal of Pharmacology | volume = 340 | issue = 2-3 | pages = 249–258 | date = December 1997 | pmid = 9537821 | doi = 10.1016/s0014-2999(97)01393-9 }}</ref>

===''Serotonin modulators and stimulators'' (SMSs)===
* [[Vilazodon]] 
* [[Vortioksetin]]

===''Serotonin antagonist and reuptake inhibitors'' (SARIs)===
* [[Nefazodon]] (Dihentikan/ditarik di banyak negara)
* [[Trazodon]] 

;Dihentikan/ditarik
* [[Etoperidon]]

===''Norepinephrine reuptake inhibitors'' (NRIs)===
* [[Reboksetin]] 
* [[Teniloksazin]] – juga merupakan antagonis reseptor 5-HT<sub>2A</sub>
* [[Viloksazin]] – juga merupakan antagonis reseptor 5-HT<sub>2B</sub> dan agonis reseptor 5-5-HT<sub>2C</sub>
;Hanya di luar label
* [[Atomoksetin]]<ref name="pmid29630286">{{cite book | vauthors = Fedder D, Patel H, Saadabadi A | chapter = Atomoxetine | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK493234/ | date = March 2023 | title = StatPearls [Internet] | location = Treasure Island (FL) | publisher = StatPearls Publishing | pmid = 29630286 }}</ref><ref name="pmid21155988">{{cite journal | vauthors = Dell'Osso B, Palazzo MC, Oldani L, Altamura AC | title = The noradrenergic action in antidepressant treatments: pharmacological and clinical aspects | journal = CNS Neurosci Ther | volume = 17 | issue = 6 | pages = 723–32 | date = December 2011 | pmid = 21155988 | pmc = 6493872 | doi = 10.1111/j.1755-5949.2010.00217.x | url = }}</ref><ref name="pmid19752841">{{cite journal | vauthors = Fleurence R, Williamson R, Jing Y, Kim E, Tran QV, Pikalov AS, Thase ME | title = A systematic review of augmentation strategies for patients with major depressive disorder | journal = Psychopharmacol Bull | volume = 42 | issue = 3 | pages = 57–90 | date = 2009 | pmid = 19752841 | doi = | url = }}</ref><ref name="pmid25295426">{{cite journal | vauthors = Corp SA, Gitlin MJ, Altshuler LL | title = A review of the use of stimulants and stimulant alternatives in treating bipolar depression and major depressive disorder | journal = J Clin Psychiatry | volume = 75 | issue = 9 | pages = 1010–8 | date = September 2014 | pmid = 25295426 | doi = 10.4088/JCP.13r08851 | url = }}</ref>

===''Norepinephrine–dopamine reuptake inhibitors'' (NDRIs)===
===Antidepresan trisiklik===
===Antidepresan tetrasiklik===

===''Monoamine Oxidase Inhibitors'' (MAOIs)===
===Antipsikotik atipikal===

===Lainnya===
===Perawatan tambahan===
===Obat kombinasi===

== Referensi ==
{{reflist}}

== Pranala luar ==
{{Wiktionary|antidepressant}}
*{{Commons category-inline|Antidepressants}}

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