Lihat sumber Asam tolfenamat

{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 470611500
| IUPAC_name = Asam 2-[(3-kloro-2-metilfenil)amino]benzoat)<ref name="Andersen">{{cite journal | vauthors = Andersen KV, Larsen S, Alhede B, Gelting N, Buchardt O | url = http://www.rsc.org/Publishing/Journals/P2/article.asp? | title = Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities | journal = J. Chem. Soc., Perkin Trans. 2 | year = 1989 | issue = 10 | pages = 1443–1447 | doi = 10.1039/P29890001443}}</ref>
| image = Tolfenamic acid FormulaV1.svg
| width = 220

<!--Clinical data-->
| tradename =  Clotam, Clotan, Tufnil
| Drugs.com = {{drugs.com|international|tolfenamic-acid}}
| routes_of_administration = [[Pemberian oral|Melalui mulut]]
| legal_AU = S4

<!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 13710-19-5
| ATC_prefix = M01
| ATC_suffix = AG02
| PubChem = 610479
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 530683
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 3G943U18KM
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01183
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 32243
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 121626

<!--Chemical data-->
| C=14 | H=12 | Cl=1 | N=1 | O=2
| smiles = Clc2cccc(Nc1ccccc1C(=O)O)c2C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = YEZNLOUZAIOMLT-UHFFFAOYSA-N
}}

'''Asam tolfenamat''' ('''Clotam, Tufnil''') adalah salah satu anggota golongan obat [[Obat antiinflamasi nonsteroid|NSAID]] [[Obat antiinflamasi nonsteroid#Turunan asam antranilat (Fenamat)|turunan asam antranilat]] (atau fenamat) yang ditemukan oleh para ilmuwan di Medica Pharmaceutical Company di Finlandia.<ref>{{cite journal | vauthors = Pentikäinen PJ, Neuvonen PJ, Backman C | title = Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent | journal = European Journal of Clinical Pharmacology | year = 1981 | volume = 19 | issue = 5 | pages = 359–65 | pmid = 7238564 | doi = 10.1007/bf00544587 | s2cid = 9428076 }}</ref> Seperti anggota golongan fenamat lainnya, ia adalah penghambat [[Siklooksigenase|COX]] dan dapat mencegah pembentukan [[prostaglandin]].<ref name=LiverTox/>

Di Britania Raya, ia digunakan sebagai pengobatan [[migrain]].<ref>NHS [https://web.archive.org/web/20111129071132/http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?condition=Migraine%20Headache&medicine=Tolfenamic%20Acid&preparation= Tolfenamic Acid (Tolfenamic acid 200mg tablets)] Diakses tanggal 2 Januari 2024.</ref> Ia umumnya tidak tersedia di AS.<ref name=LiverTox>NIH LiverTox Database [http://livertox.nih.gov/MefenamicAcid.htm Mefenamic Acid] Terakhir diperbarui 23 Juni 2015. Diakses tanggal 2 Januari 2024. Kutipan: "(fenamat umumnya tidak tersedia di Amerika Serikat, seperti asam tolfenamat dan asam flufenamat)"</ref> Obat ini tersedia di beberapa negara Asia, Amerika Latin, dan Eropa sebagai [[obat generik]] untuk manusia dan hewan.<ref>Drugs.com [https://www.drugs.com/international/tolfenamic-acid.html Drugs.com international listings for tolfenamic acid] Diakses tanggal 2 Januari 2024.</ref>
==Referensi==
{{reflist}}
==Pranala luar==
* {{en}} [http://www.diseasesdatabase.com/ddb31603.htm Informasi asam tolfenamat] (Basis Data Penyakit)

{{Obat antiinflamasi nonsteroid}}
{{GABAAR PAMs}}

{{DEFAULTSORT:Tolfenamat, asam}}
[[Kategori:Antiperadangan nonsteroid]]
[[Kategori:Antipiretik]]
[[Kategori:Kloroarena]]
[[Kategori:Asam antranilat]]
[[Kategori:Modulator alosterik positif reseptor GABAA]]
[[Kategori:Analgesik]]
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