Lihat sumber Trazodon

{{Infobox drug|drug_name=|image=Trazodone.svg|width=250px|alt=|image2=Trazodone-from-HCl-xtal-Mercury-3D-balls.png|width2=250px|caption=<!-- | type = mab / vaccine / combo -->|type=<!-- Names -->|tradename=Many brand names worldwide<ref name=genericnames>{{cite web |title=Trazodone |url=https://www.drugs.com/international/trazodone.html |website=Drugs.com |accessdate=9 February 2019 |language=en |archive-date=16 September 2018 |archive-url=https://web.archive.org/web/20180916022006/https://www.drugs.com/international/trazodone.html |url-status=live }}</ref>|synonyms=AF-1161|IUPAC_name=2-<nowiki/>{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-''a'']pyridin-3(2''H'')-one

<!-- Clinical data -->|pregnancy_AU=|pregnancy_US=C|pregnancy_category=|routes_of_administration=[[Oral administration|By mouth]] ([[tablet (pharmacy)|tablets]])|dependency_liability=None<ref name=Hub2001>{{cite book |last1=Hubbard |first1=John R. |last2=Martin |first2=Peter R. |title=Substance Abuse in the Mentally and Physically Disabled |date=2001 |publisher=CRC Press |isbn=9780824744977 |page=26 |url=https://books.google.com/books?id=MY1kFYk98mQC&pg=PA26 |language=en |access-date=6 August 2020 |archive-date=1 August 2020 |archive-url=https://web.archive.org/web/20200801020251/https://books.google.com/books?id=MY1kFYk98mQC&pg=PA26 |url-status=live }}</ref>|Drugs.com={{drugs.com|monograph|trazodone-hydrochloride}}|MedlinePlus=a681038

<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=|DailyMedID=Trazodone|licence_US=|licence_EU=<!-- Pharmacokinetic data -->|bioavailability=[[Oral administration|By mouth]]: 65%<ref name="DrugPoint">Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. {{Failed verification|date=April 2017|reason=search for "Trazodone" fails on Truven Web site}}</ref>|protein_bound=89–95%<ref>{{cite web|url=http://www.drugbank.ca/drugs/DB00656|title=Trazodone|website=DrugBank|accessdate=7 June 2015|archive-date=12 July 2017|archive-url=https://web.archive.org/web/20170712013038/https://www.drugbank.ca/drugs/DB00656|url-status=live}}</ref>|metabolism=[[Liver]] ([[CYP3A4]])<ref>{{cite book |last1=Lemke |first1=Thomas L. |last2=Williams |first2=David A. |title=Foye's Principles of Medicinal Chemistry |date=2012 |publisher=Lippincott Williams & Wilkins |isbn=9781609133450 |page=615 |url=https://books.google.ca/books?id=Sd6ot9ul-bUC&pg=PA615 |language=en |access-date=6 August 2020 |archive-date=17 September 2018 |archive-url=https://web.archive.org/web/20180917215454/https://books.google.ca/books?id=Sd6ot9ul-bUC&pg=PA615 |url-status=live }}</ref>|elimination_half-life=Trazodone {{abbr|IR|immediate-release}}: 7 hours<ref name="DrugPoint" /><br />Trazodone {{abbr|ER|extended-release}}: 10 hours<ref name="DrugPoint" /><br />{{abbrlink|mCPP|meta-Chlorophenylpiperazine}}: 4–8 hours<ref name="SchatzbergNemeroff2017">{{cite book|vauthors = Schatzberg AF,Nemeroff CB|title=The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition|url=https://books.google.com/books?id=KfHEDgAAQBAJ&pg=PA460|year=2017|publisher=American Psychiatric Pub|isbn=978-1-58562-523-9|pages=460–}}</ref>|excretion=[[Urine]]: 70–75%<ref name="DrugPoint" /><br />[[Feces]]: 21%<ref name="DrugPoint" />

<!-- Chemical and physical data -->|C=19|Cl=1|H=22|N=5|O=1|smiles=Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4|StdInChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChIKey=PHLBKPHSAVXXEF-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|melting_point=87}}

'''Trazodon''' adalah obat golongan [[antidepresan]] . <ref name="AHFS2018">{{Cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|archive-date=19 September 2018|access-date=8 January 2018|url-status=live}}</ref> Obat ini bisa digunakan untuk mengatasi [[gangguan depresi mayor]], [[gangguan kecemasan]], [[insomnia]] dan, juga  bisa dikombinasikan dengan obat lain untuk mengatasi, ketergantungan alkohol . <ref name="AHFS2018" /> <ref name="CFPC2021">{{Cite web|last=Ton|first=Joey|date=15 November 2021|title=#302 Still awake? Trazodone for insomnia|url=https://cfpclearn.ca/tfp302/|website=CFPCLearn|archive-url=https://web.archive.org/web/20230328114109/https://cfpclearn.ca/tfp302/|archive-date=28 March 2023|access-date=14 June 2023|url-status=live}}</ref> Trazodone bisa dikonsumsi secara oral. <ref name="AHFS2018" />

Kejadian efek samping yang kerap terjadi yakni [[Xerostomia|mulut kering]], rasa ingin pingsan, muntah, dan rasa sakit kepala. <ref name="AHFS2018" /> Efek samping yang parah muncul rasa ingin [[bunuh diri]], [[mania]], [[Aritmia]], dan [[Priapisme]] . <ref name="AHFS2018" /> Belum diketahui obat ini aman untuk masa [[kehamilan]], dan masa [[menyusui]] .<ref>{{Cite web|title=Trazodone Use During Pregnancy|url=https://www.drugs.com/pregnancy/trazodone.html|website=Drugs.com|archive-url=https://web.archive.org/web/20190810191222/https://www.drugs.com/pregnancy/trazodone.html|archive-date=10 August 2019|access-date=7 January 2018|url-status=live}}</ref> Trazodone merupakan senyawa fenilpiperazin dari kelas antagonis serotonin dan penghambat reuptake (SARI).<ref>{{Cite book|last=Stahl|first=Stephen M.|date=2008|url=https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|title=Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications|publisher=Cambridge University Press|isbn=9780521857024|page=567|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190811032910/https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|archive-date=11 August 2019|url-status=live}}</ref> <ref>{{Cite book|last=Lemke|first=Thomas L.|last2=Williams|first2=David A.|date=2008|url=https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|title=Foye's Principles of Medicinal Chemistry|publisher=Lippincott Williams & Wilkins|isbn=9780781768795|page=586|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190812031919/https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|archive-date=12 August 2019|url-status=live}}</ref> Obat trazodone juga memiliki efek lain yakni rasa menenangkan. <ref name="BNF69">{{Cite book|date=2015|title=British national formulary: BNF 69|url=https://archive.org/details/bnf69britishnati0000unse|publisher=British Medical Association|isbn=9780857111562|edition=69th|pages=[https://archive.org/details/bnf69britishnati0000unse/page/257 257]–258}}</ref>

== Referensi ==

[[Kategori:Antidepresan]]
[[Kategori:Obat hewan]]
[[Kategori:Triazolopiridina]]
[[Kategori:Urea]]
[[Kategori:Penghambat pengambilan kembali serotonin]]
[[Kategori:Antagonis reseptor H1]]
[[Kategori:Anksiolitik]]
[[Kategori:Hipnotik]]
[[Kategori:Penghalang alfa-1]]
[[Kategori:Agonis 5-HT1A]]
[[Kategori:Antagonis 5-HT2A]]
<references />{{Farmasi-stub}}