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'''KEGG''' '''(Kyoto Encyclopedia of Genes and Genomes)''' adalah kumpulan database yang berkaitan dengan [[genome]], [[biological pathway]], [[penyakit]], [[obat]], dan [[bahan kimia]]. KEGG digunakan untuk riset dan pengajaran [[bioinformatika]], termasuk analisis data dalam [[genomika]], [[:en:metagenomics|metagenomika]], [[metabolomika]] dan studi [[:en:omics|omika]] lainnya, perancangan model dan simulasi dalam [[sistems biologi]], serta [[:en:translational research|riset translational]] dalam [[:en:drug development|pengembangan obat]].
'''KEGG''' '''(Kyoto Encyclopedia of Genes and Genomes)''' adalah kumpulan database yang berkaitan dengan [[genom]], [[:en:biological pathway|pathway biologi]], [[penyakit]], [[obat]], dan [[bahan kimia]]. KEGG digunakan untuk riset dan pengajaran [[bioinformatika]], termasuk analisis data dalam [[genomika]], [[:en:metagenomics|metagenomika]], [[metabolomika]] dan studi [[:en:omics|omika]] lainnya, perancangan model dan simulasi dalam [[sistem biologi]], serta [[:en:translational research|riset translational]] dalam [[:en:drug development|pengembangan obat]].
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==Introduction==


== Sejarah ==
⚫
The KEGG database project was initiated in 1995 by Minoru Kanehisa, Professor at the Institute for Chemical Research, [[Kyoto University]], under the then ongoing Japanese [[Human Genome Project|Human Genome Program]].<ref name="pmid10592173">{{cite journal| author=Kanehisa M, Goto S | title=KEGG: Kyoto Encyclopedia of Genes and Genomes | journal=Nucleic Acids Res | year=2000 | volume=28 | issue=1 | pages=27–30 | pmid=10592173 | doi=10.1093/nar/28.1.27 | pmc=102409 }}</ref><ref name="pmid9287494">{{cite journal| author=Kanehisa M | title=A database for post-genome analysis | journal=Trends Genet | year=1997 | volume=13 | issue=9 | pages=375–6 | pmid=9287494 | doi=10.1016/S0168-9525(97)01223-7 }}</ref> Foreseeing the need for a computerized resource that can be used for biological interpretation of [[genome project|genome sequence data]], he started developing the KEGG PATHWAY database. It is a collection of manually drawn KEGG pathway maps representing experimental knowledge on [[metabolism]] and various other functions of the [[cell (biology)|cell]] and the [[organism]]. Each pathway map contains a network of molecular interactions and reactions and is designed to link [[gene]]s in the genome to [[gene product]]s (mostly [[protein]]s) in the pathway. This has enabled the analysis called KEGG pathway mapping, whereby the gene content in the genome is compared with the KEGG PATHWAY database to examine which pathways and associated functions are likely to be encoded in the genome.


⚫
Proyek database KEGG dimulai pada tahun 1995 oleh Minoru Kanehisa, Professor pada Institute for Chemical Research, [[Kyoto University]], yang saat itu berada di bawah [[:en:Human Genome Project|Human Genome Program]] [[Jepang]].<ref name="pmid10592173">{{cite journal| author=Kanehisa M, Goto S | title=KEGG: Kyoto Encyclopedia of Genes and Genomes | journal=Nucleic Acids Res | year=2000 | volume=28 | issue=1 | pages=27–30 | pmid=10592173 | doi=10.1093/nar/28.1.27 | pmc=102409 }}</ref><ref name="pmid9287494">{{cite journal| author=Kanehisa M | title=A database for post-genome analysis | journal=Trends Genet | year=1997 | volume=13 | issue=9 | pages=375–6 | pmid=9287494 | doi=10.1016/S0168-9525(97)01223-7 }}</ref><!-- Foreseeing the need for a computerized resource that can be used for biological interpretation of [[genome project|genome sequence data]], he started developing the KEGG PATHWAY database. It is a collection of manually drawn KEGG pathway maps representing experimental knowledge on [[metabolism]] and various other functions of the [[cell (biology)|cell]] and the [[organism]]. Each pathway map contains a network of molecular interactions and reactions and is designed to link [[gene]]s in the genome to [[gene product]]s (mostly [[protein]]s) in the pathway. This has enabled the analysis called KEGG pathway mapping, whereby the gene content in the genome is compared with the KEGG PATHWAY database to examine which pathways and associated functions are likely to be encoded in the genome.
⚫
According to the developers, KEGG is a "computer representation" of the [[biological system]].<ref name="pmid16381885">{{cite journal| author=Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M | title=From genomics to chemical genomics: new developments in KEGG | journal=Nucleic Acids Res | year=2006 | volume=34 | issue=Database issue | pages=D354–7 | pmid=16381885 | doi=10.1093/nar/gkj102 | pmc=1347464 }}</ref> It integrates building blocks and wiring diagrams of the system — more specifically, genetic building blocks of genes and proteins, chemical building blocks of [[small molecule]]s and reactions, and wiring diagrams of molecular interaction and reaction networks. This concept is realized in the following databases of KEGG, which are categorized into systems, genomic, chemical, and health information.<ref name="pmid24214961">{{cite journal| author=Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, Tanabe M | title=Data, information, knowledge and principle: back to metabolism in KEGG | journal=Nucleic Acids Res | year=2014 | volume=42 | issue=Database issue | pages=D199-205 | pmid=24214961 | doi=10.1093/nar/gkt1076 | pmc=3965122 }}</ref>
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⚫
Menurut para developernya, KEGG merupakan suatu "computer representation" dari [[sistem biologi]].<ref name="pmid16381885">{{cite journal| author=Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M | title=From genomics to chemical genomics: new developments in KEGG | journal=Nucleic Acids Res | year=2006 | volume=34 | issue=Database issue | pages=D354–7 | pmid=16381885 | doi=10.1093/nar/gkj102 | pmc=1347464 }}</ref><!-- It integrates building blocks and wiring diagrams of the system—more specifically, genetic building blocks of genes and proteins, chemical building blocks of [[small molecule]]s and reactions, and wiring diagrams of molecular interaction and reaction networks. This concept is realized in the following databases of KEGG, which are categorized into systems, genomic, chemical, and health information.<ref name="pmid24214961">{{cite journal| author=Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, Tanabe M | title=Data, information, knowledge and principle: back to metabolism in KEGG | journal=Nucleic Acids Res | year=2014 | volume=42 | issue=Database issue | pages=D199-205 | pmid=24214961 | doi=10.1093/nar/gkt1076 | pmc=3965122 }}</ref>
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* Informasi sistem
* Informasi sistem
** PATHWAY — peta [[biological pathway|pathway]] untuk fungsi-fungsi seluler dan organismal
** PATHWAY—peta [[:en:biological pathway|pathway]] untuk fungsi-fungsi seluler dan organismal
** MODULE — modul atau unit fungsional gen
** MODULE—modul atau unit fungsional gen
** BRITE — klasifikasi hierarkis entiti biologi
** BRITE—klasifikasi hierarkis entiti biologi
* Informasi genomik
* Informasi genomik
** GENOME — [[genome]] lengkap
** GENOME—[[genom]] lengkap
** GENES — [[gen]] dan [[protein]] dalam genome lengkap
** GENES—[[gen]] dan [[protein]] dalam genom lengkap
** ORTHOLOGY — [[ortholog]] groups of genes in the complete genomes
** ORTHOLOGY—group [[:en:ortholog|ortologi]] gen dalam genom lengkap
* Informasi kimia
* Informasi kimia
** COMPOUND, GLYCAN — [[senyawa kimia]] dan [[glycan]]
** COMPOUND, GLYCAN—[[senyawa kimia]] dan [[glikan]]
** REACTION, RPAIR, RCLASS — [[reaksi kimia]]
** REACTION, RPAIR, RCLASS—[[reaksi kimia]]
** ENZYME — [[enzyme nomenclature]]
** ENZYME—[[:en:enzyme nomenclature|nomenklatur enzim]]
* Informasi kesehatan
* Informasi kesehatan
** DISEASE — [[penyakit]] manusia
** DISEASE—[[penyakit]] manusia
** DRUG — [[approved drugs]]
** DRUG—[[:en:approved drugs|obat yang sudah diberi izin]]
** ENVIRON — [[crude drug]] dan bahan terkait kesehatan
** ENVIRON—[[:en:crude drug|obat mentah]] dan bahan terkait kesehatan
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==Database==
==Database==
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* [[Gene Disease Database]]
* [[Gene Disease Database]]


==Referensi==
== Referensi ==
{{Reflist}}
{{Reflist}}


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* [http://www.kegg.jp/ KEGG website]
* [http://www.kegg.jp/ KEGG website]
* [http://www.genome.jp/kegg/ GenomeNet mirror site]
* [http://www.genome.jp/kegg/ GenomeNet mirror site]
* The [http://metadatabase.org/wiki/KEGG entry for KEGG] dalam [[MetaBase]]
* The [http://metadatabase.org/wiki/KEGG entry for KEGG] {{Webarchive|url=https://web.archive.org/web/20120402032246/http://metadatabase.org/wiki/KEGG |date=2012-04-02 }} dalam [[MetaBase]]

{{Authority control}}


{{DEFAULTSORT:Kegg}}
{{DEFAULTSORT:Kegg}}
[[Kategori:Database biologi]]
[[Kategori:Database biologi]]
[[Kategori:Sistem biologi]]
[[Kategori:Biologi]]
[[Kategori:Online databases]]
[[Kategori:Online databases]]
[[Kategori:Kimia]]

Revisi terkini sejak 22 Januari 2023 15.05

KEGG
Konten
DeskripsiBioinformatics resource for deciphering the genome.
OrganismeAll
Kontak
Pusat penelitianKyoto University
LaboratoriumKanehisa Laboratories
Kutipan utamaPMID 10592173
Tanggal rilis1995
Akses
Situs webwww.kegg.jp
URL layanan webREST see KEGG API
Perangkat
WebKEGG Mapper
Lain-lain

KEGG (Kyoto Encyclopedia of Genes and Genomes) adalah kumpulan database yang berkaitan dengan genom, pathway biologi, penyakit, obat, dan bahan kimia. KEGG digunakan untuk riset dan pengajaran bioinformatika, termasuk analisis data dalam genomika, metagenomika, metabolomika dan studi omika lainnya, perancangan model dan simulasi dalam sistem biologi, serta riset translational dalam pengembangan obat.

Sejarah

[sunting | sunting sumber]

Proyek database KEGG dimulai pada tahun 1995 oleh Minoru Kanehisa, Professor pada Institute for Chemical Research, Kyoto University, yang saat itu berada di bawah Human Genome Program Jepang.[1][2] Menurut para developernya, KEGG merupakan suatu "computer representation" dari sistem biologi.[3]

Lihat pula

[sunting | sunting sumber]

Referensi

[sunting | sunting sumber]
  1. ^ Kanehisa M, Goto S (2000). "KEGG: Kyoto Encyclopedia of Genes and Genomes". Nucleic Acids Res. 28 (1): 27–30. doi:10.1093/nar/28.1.27. PMC 102409 alt=Dapat diakses gratis. PMID 10592173. 
  2. ^ Kanehisa M (1997). "A database for post-genome analysis". Trends Genet. 13 (9): 375–6. doi:10.1016/S0168-9525(97)01223-7. PMID 9287494. 
  3. ^ Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M (2006). "From genomics to chemical genomics: new developments in KEGG". Nucleic Acids Res. 34 (Database issue): D354–7. doi:10.1093/nar/gkj102. PMC 1347464 alt=Dapat diakses gratis. PMID 16381885. 

Pranala luar

[sunting | sunting sumber]
Wikidata memiliki sebuah properti, P665, untuk KEGG IDs (lihat penggunaan)
Diperoleh dari "https://wiki-indonesia.club/w/index.php?title=KEGG&oldid=22718564"