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<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=|DailyMedID=Quetiapine|licence_US=Quetiapine|licence_EU=<!-- Pharmacokinetic data -->|bioavailability=100%<ref name=Medscape>{{cite web|title=quetiapine (Rx) - Seroquel, Seroquel XR|url=http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|website=Medscape Reference|publisher=WebMD|access-date=11 October 2013|url-status = live|archive-url=https://web.archive.org/web/20131020163700/http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|archive-date=20 October 2013|df=}}</ref>|protein_bound=83%<ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref>|metabolism=[[Liver]] via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)<ref name = GG>{{cite book|vauthors=Brunton L, Chabner B, Knollman B|title=Goodman and Gilman's The Pharmacological Basis of Therapeutics|edition=12th|publisher=McGraw Hill Professional|year=2010|isbn=978-0071624428|url=https://books.google.com/books?id=bVUfAQAAQBAJ|access-date=2018-07-23|archive-date=2020-08-06|archive-url=https://web.archive.org/web/20200806023105/https://books.google.com/books?id=bVUfAQAAQBAJ|url-status=live}}</ref>|elimination_half-life=7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)<ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref><ref name = DD>Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref>|excretion=[[Kidney]] (73%), faeces (20%)<ref name=Medscape>{{cite web|title=quetiapine (Rx) - Seroquel, Seroquel XR|url=http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|website=Medscape Reference|publisher=WebMD|access-date=11 October 2013|url-status = live|archive-url=https://web.archive.org/web/20131020163700/http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|archive-date=20 October 2013|df=}}</ref><ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref><ref name = DD>Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref><ref name=DM>{{cite web|title=QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]|website=DailyMed|publisher=Ascend Laboratories, LLC|date=October 2013|access-date=26 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|url-status = live|archive-url=https://web.archive.org/web/20131202224630/http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|archive-date=2 December 2013|df=}}</ref>
<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=|DailyMedID=Quetiapine|licence_US=Quetiapine|licence_EU=<!-- Pharmacokinetic data -->|bioavailability=100%<ref name=Medscape>{{cite web|title=quetiapine (Rx) - Seroquel, Seroquel XR|url=http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|website=Medscape Reference|publisher=WebMD|access-date=11 October 2013|url-status = live|archive-url=https://web.archive.org/web/20131020163700/http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|archive-date=20 October 2013|df=}}</ref>|protein_bound=83%<ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref>|metabolism=[[Liver]] via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)<ref name = GG>{{cite book|vauthors=Brunton L, Chabner B, Knollman B|title=Goodman and Gilman's The Pharmacological Basis of Therapeutics|edition=12th|publisher=McGraw Hill Professional|year=2010|isbn=978-0071624428|url=https://books.google.com/books?id=bVUfAQAAQBAJ|access-date=2018-07-23|archive-date=2020-08-06|archive-url=https://web.archive.org/web/20200806023105/https://books.google.com/books?id=bVUfAQAAQBAJ|url-status=live}}</ref>|elimination_half-life=7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)<ref name=EMC /><ref name=DD>Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref>|excretion=[[Kidney]] (73%), faeces (20%)<ref name=Medscape /><ref name=EMC /><ref name=DD /><ref name=DM>{{cite web|title=QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]|website=DailyMed|publisher=Ascend Laboratories, LLC|date=October 2013|access-date=26 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|url-status = live|archive-url=https://web.archive.org/web/20131202224630/http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|archive-date=2 December 2013|df=}}</ref>


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'''Quetiapine''' adalah obat antipsikotik atipikal yang digunakan untuk mengatasi [[skizofrenia]], [[gangguan bipolar]], dan [[gangguan depresi mayor]] . <ref name="AHFS2017">{{Cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017}}</ref> <ref name="Cochrane2010">{{Cite journal|date=December 2010|title=Second-generation antipsychotics for major depressive disorder and dysthymia|journal=The Cochrane Database of Systematic Reviews|issue=12|pages=CD008121|doi=10.1002/14651858.CD008121.pub2|pmid=21154393|vauthors=Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S}}</ref> Walaupun obat ini sering digunakan untuk obat tidur disebabkan efeknya yang menenangkan, walaupun sebenarnya hal ini tidak melebihi efek samping obat ini. <ref>{{Cite journal|date=March 2014|title=Quetiapine for insomnia: A review of the literature|url=http://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|journal=American Journal of Health-System Pharmacy|volume=71|issue=5|pages=394–402|doi=10.2146/ajhp130221|pmid=24534594|archive-url=https://web.archive.org/web/20200219013637/https://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|archive-date=2020-02-19|access-date=2020-05-04|vauthors=Anderson SL, Vande Griend JP|url-status=dead}}</ref> Rute pemberian obat ini melalui oral. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>
'''Kuetiapin''' adalah obat antipsikotik atipikal yang digunakan untuk mengatasi [[skizofrenia]], [[gangguan bipolar]], dan [[gangguan depresi mayor]] . <ref name="AHFS2017">{{Cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017}}</ref> <ref name="Cochrane2010">{{Cite journal|date=December 2010|title=Second-generation antipsychotics for major depressive disorder and dysthymia|journal=The Cochrane Database of Systematic Reviews|issue=12|pages=CD008121|doi=10.1002/14651858.CD008121.pub2|pmid=21154393|vauthors=Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S}}</ref> Walaupun obat ini sering digunakan untuk obat tidur disebabkan efeknya yang menenangkan, walaupun sebenarnya hal ini tidak melebihi efek samping obat ini.<ref>{{Cite journal|date=March 2014|title=Quetiapine for insomnia: A review of the literature|url=http://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|journal=American Journal of Health-System Pharmacy|volume=71|issue=5|pages=394–402|doi=10.2146/ajhp130221|pmid=24534594|archive-url=https://web.archive.org/web/20200219013637/https://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|archive-date=2020-02-19|access-date=2020-05-04|vauthors=Anderson SL, Vande Griend JP|url-status=dead}}</ref> Rute pemberian obat ini melalui oral. <ref name="AHFS2017" />


Efek samping yang umum juga muncul seperti rasa mengantuk, [[sembelit]], berat badan bertambah, dan juga [[xerostomia]] . <ref name="AHFS2017">{{Cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/quetiapine-fumarate.html "Quetiapine Fumarate"]. The American Society of Health-System Pharmacists. [https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html Archived] from the original on 29 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">26 March</span> 2017</span>.</cite></ref> Efek samping lainnya dari obat ini yakni bisa meningkatkan [[hipotensi ortostatik]], [[Sawan|kejang]], [[priapisme]], [[hiperglikemia]], tardive dyskinesia, dan sindrom neuroleptik maligna . <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref> Pada lanjut usia dengan kondisi [[demensia]], penggunaan obat ini bisa meningkatkan risiko kematian. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref> Penggunaan pada [[kehamilan]] [[Kehamilan|trimester ketiga]] bisa menyebabkan gangguan pergerakan pada bayi selama beberapa waktu setelah melahirkan. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>Mekanisme kerja obat ini dengan cara memblokir sejumlah reseptor termasuk [[Reseptor serotonin|serotonin]] dan dopamin . <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>
Efek samping yang umum juga muncul seperti rasa mengantuk, [[sembelit]], berat badan bertambah, dan juga [[xerostomia]] . <ref name="AHFS2017" /> Efek samping lainnya dari obat ini yakni bisa meningkatkan [[hipotensi ortostatik]], [[Sawan|kejang]], [[priapisme]], [[hiperglikemia]], tardive dyskinesia, dan sindrom neuroleptik maligna . <ref name="AHFS2017" /> Pada lanjut usia dengan kondisi [[demensia]], penggunaan obat ini bisa meningkatkan risiko kematian. <ref name="AHFS2017" /> Penggunaan pada [[kehamilan]] [[Kehamilan|trimester ketiga]] bisa menyebabkan gangguan pergerakan pada bayi selama beberapa waktu setelah melahirkan. <ref name="AHFS2017" />Mekanisme kerja obat ini dengan cara memblokir sejumlah reseptor termasuk [[Reseptor serotonin|serotonin]] dan dopamin . <ref name="AHFS2017" />


== Referensi ==
== Referensi ==


[[Kategori:Obat]]
[[Kategori:Hipnotik]]
[[Kategori:Farmasi]]
[[Kategori:Antidepresan]]
[[Kategori:Penghalang alfa-1]]
[[Kategori:Penghalang alfa-2]]
[[Kategori:Antipsikotik atipikal]]
[[Kategori:Obat yang dikembangkan oleh AstraZeneca]]
[[Kategori:Dibenzotiazepina]]
[[Kategori:Eter glikol]]
[[Kategori:Antagonis reseptor H1]]
[[Kategori:Antagonis 5-HT2A]]
[[Kategori:Piperazina]]
[[Kategori:Alkohol primer]]
[[Kategori:Sedatif]]
[[Kategori:Obat Esensial Organisasi Kesehatan Dunia]]
<references />{{Farmasi-stub}}
<references />{{Farmasi-stub}}

Revisi terkini sejak 6 Agustus 2024 14.45

Nama sistematis (IUPAC)
2-(2-(4-Dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Data klinis
Nama dagang Seroquel, Temprolide, others
AHFS/Drugs.com monograph
MedlinePlus a698019
Data lisensi US Daily Med:pranala
Kat. kehamilan B3(AU) C(US)
Status hukum Harus dengan resep dokter (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US)
Rute By mouth
Data farmakokinetik
Bioavailabilitas 100%[1]
Ikatan protein 83%[2]
Metabolisme Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[3]
Waktu paruh 7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[2][4]
Ekskresi Kidney (73%), faeces (20%)[1][2][4][5]
Pengenal
Kode ATC ?
Data kimia
Rumus C21H25N3O2S 
SMILES eMolecules & PubChem

  • InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 YaY
    Key:URKOMYMAXPYINW-UHFFFAOYSA-N YaY

Data fisik
Kelarutan dalam air 3.29 mg/mL (20 °C)

Kuetiapin adalah obat antipsikotik atipikal yang digunakan untuk mengatasi skizofrenia, gangguan bipolar, dan gangguan depresi mayor . [6] [7] Walaupun obat ini sering digunakan untuk obat tidur disebabkan efeknya yang menenangkan, walaupun sebenarnya hal ini tidak melebihi efek samping obat ini.[8] Rute pemberian obat ini melalui oral. [6]

Efek samping yang umum juga muncul seperti rasa mengantuk, sembelit, berat badan bertambah, dan juga xerostomia . [6] Efek samping lainnya dari obat ini yakni bisa meningkatkan hipotensi ortostatik, kejang, priapisme, hiperglikemia, tardive dyskinesia, dan sindrom neuroleptik maligna . [6] Pada lanjut usia dengan kondisi demensia, penggunaan obat ini bisa meningkatkan risiko kematian. [6] Penggunaan pada kehamilan trimester ketiga bisa menyebabkan gangguan pergerakan pada bayi selama beberapa waktu setelah melahirkan. [6]Mekanisme kerja obat ini dengan cara memblokir sejumlah reseptor termasuk serotonin dan dopamin . [6]

Referensi

[sunting | sunting sumber]
  1. ^ a b "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Diarsipkan dari versi asli tanggal 20 October 2013. Diakses tanggal 11 October 2013. 
  2. ^ a b c "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Diarsipkan dari versi asli tanggal 20 October 2013. Diakses tanggal 20 October 2013. 
  3. ^ Brunton L, Chabner B, Knollman B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (edisi ke-12th). McGraw Hill Professional. ISBN 978-0071624428. Diarsipkan dari versi asli tanggal 2020-08-06. Diakses tanggal 2018-07-23. 
  4. ^ a b Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
  5. ^ "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]". DailyMed. Ascend Laboratories, LLC. October 2013. Diarsipkan dari versi asli tanggal 2 December 2013. Diakses tanggal 26 November 2013. 
  6. ^ a b c d e f g "Quetiapine Fumarate". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 29 August 2017. Diakses tanggal 26 March 2017. 
  7. ^ Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. doi:10.1002/14651858.CD008121.pub2. PMID 21154393. 
  8. ^ Anderson SL, Vande Griend JP (March 2014). "Quetiapine for insomnia: A review of the literature" (PDF). American Journal of Health-System Pharmacy. 71 (5): 394–402. doi:10.2146/ajhp130221. PMID 24534594. Diarsipkan dari versi asli (PDF) tanggal 2020-02-19. Diakses tanggal 2020-05-04. 
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