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<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability = 87%<ref name = ABILIFY>{{cite web|title=Product Information for ABILIFY<sup>TM</sup> Aripiprazole Tablets & Orally Disintegrating Tablets|work = TGA eBusiness Services|publisher = Bristol-Myers Squibb Australia Pty Ltd|date=1 November 2012|accessdate=22 October 2013|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-03820-3}}</ref>
| bioavailability = 87%<ref name = ABILIFY>{{cite web|title=Product Information for ABILIFY<sup>TM</sup> Aripiprazole Tablets & Orally Disintegrating Tablets|work = TGA eBusiness Services|publisher = Bristol-Myers Squibb Australia Pty Ltd|date=1 November 2012|accessdate=22 October 2013|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-03820-3}}</ref>
<ref name = DM>{{cite web|title=ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]|date=April 2013|accessdate=22 October 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c040bd1d-45b7-49f2-93ea-aed7220b30ac|publisher=Otsuka America Pharmaceutical, Inc.|work=DailyMed}}</ref><ref name = EMC>{{cite web|title=Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)|date=20 September 2013|accessdate=22 October 2013|publisher=Otsuka Pharmaceuticals (UK) Ltd|work=electronic Medicines Compendium|url=http://www.medicines.org.uk/emc/medicine/18494/SPC/Abilify+Tablets%2c+Orodispersible+Tablets%2c+Oral+Solution/}}</ref><ref name = EMA>{{cite web|title=ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS|work=European Medicines Agency|publisher=Otsuka Pharmaceutical Europe Ltd.|accessdate=22 October 2013|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000471/WC500020170.pdf}}</ref>
<ref name = DM>{{cite web|title=ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]|date=April 2013|accessdate=22 October 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c040bd1d-45b7-49f2-93ea-aed7220b30ac|publisher=Otsuka America Pharmaceutical, Inc.|work=DailyMed}}</ref><ref name = EMC>{{cite web|title=Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)|date=20 September 2013|accessdate=22 October 2013|publisher=Otsuka Pharmaceuticals (UK) Ltd|work=electronic Medicines Compendium|url=http://www.medicines.org.uk/emc/medicine/18494/SPC/Abilify+Tablets%2c+Orodispersible+Tablets%2c+Oral+Solution/|archive-date=2016-03-04|archive-url=https://web.archive.org/web/20160304001126/http://www.medicines.org.uk/emc/medicine/18494/SPC/Abilify+Tablets,+Orodispersible+Tablets,+Oral+Solution/|dead-url=yes}}</ref><ref name = EMA>{{cite web|title=ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS|work=European Medicines Agency|publisher=Otsuka Pharmaceutical Europe Ltd.|accessdate=22 October 2013|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000471/WC500020170.pdf}}</ref>
| protein_bound = >99%<ref name = ABILIFY/><ref name = DM/><ref name = EMC/><ref name = EMA/>
| protein_bound = >99%<ref name = ABILIFY/><ref name = DM/><ref name = EMC/><ref name = EMA/>
| metabolism = [[Hepatik]] (hati; terutama via [[CYP3A4]] dan [[CYP2D6]]<ref name = ABILIFY/><ref name = DM/><ref name = EMC/><ref name = EMA/>)
| metabolism = [[Hepatik]] (hati; terutama via [[CYP3A4]] dan [[CYP2D6]]<ref name = ABILIFY/><ref name = DM/><ref name = EMC/><ref name = EMA/>)
Baris 62: Baris 62:
}}
}}


'''Aripiprazol''', dijual dengan nama merek Abilify adalah [[antipsikotik atipikal]]. Obat dianjurkan dan terutama digunakan dalam pengobatan [[skizofrenia]] dan [[gangguan bipolar]]. <ref name=AHFS>{{cite web|title=abilify|url=http://www.drugs.com/monograph/abilify.html|work=The American Society of Health-System Pharmacists|accessdate=3 April 2011}}</ref> Kegunaan lain termasuk sebagai terapi tambahan pada penyakit [[depresi]], gangguan tic, dan iritabilitas yang berhubungan dengan [[autisme]].<ref>http://www.webmd.com/drugs/drug-64439-Abilify+Oral.aspx?drugid=64439&drugname=Abilify+Oral&source=1</ref> Menurut review Cochrane, bukti bentuk oral pada skizofrenia tidak cukup untuk menentukan efek pada fungsi umum.<ref name=Coch2011>{{cite journal |vauthors=Belgamwar RB, El-Sayeh HG | title = Aripiprazole versus placebo for schizophrenia. | journal = The Cochrane database of systematic reviews | issue = 8 | pages = CD006622 | date = Aug 10, 2011 | pmid = 21833956 | doi=10.1002/14651858.CD006622.pub2}}</ref> Selain itu, karena banyak orang putus obat selama percobaan sebelum mereka selesai, keseluruhan kekuatan kesimpulan adalah rendah.<ref name=Coch2011/>
'''Aripiprazol''', dijual dengan nama merek Abilify adalah [[antipsikotik atipikal]]. Obat dianjurkan dan terutama digunakan dalam pengobatan [[skizofrenia]] dan [[gangguan bipolar]].<ref name=AHFS>{{cite web|title=abilify|url=http://www.drugs.com/monograph/abilify.html|work=The American Society of Health-System Pharmacists|accessdate=3 April 2011}}</ref> Kegunaan lain termasuk sebagai terapi tambahan pada penyakit [[depresi]], gangguan tic, dan [[iritabilitas]] yang berhubungan dengan [[autisme]].<ref>http://www.webmd.com/drugs/drug-64439-Abilify+Oral.aspx?drugid=64439&drugname=Abilify+Oral&source=1</ref> Menurut review Cochrane, bukti bentuk oral pada skizofrenia tidak cukup untuk menentukan efek pada fungsi umum.<ref name=Coch2011>{{cite journal |vauthors=Belgamwar RB, El-Sayeh HG | title = Aripiprazole versus placebo for schizophrenia. | journal = The Cochrane database of systematic reviews | issue = 8 | pages = CD006622 | date = Aug 10, 2011 | pmid = 21833956 | doi=10.1002/14651858.CD006622.pub2}}</ref> Selain itu, karena banyak orang putus obat selama percobaan sebelum mereka selesai, keseluruhan kekuatan kesimpulan adalah rendah.<ref name=Coch2011/>


== Referensi ==
== Referensi ==
{{reflist}}

[[Kategori:Antipsikotik atipikal]]
[[Kategori:Antagonis 5-HT2A]]
[[Kategori:Antagonis 5-HT2B]]
[[Kategori:Agonis 5-HT2C]]
[[Kategori:Antagonis 5-HT7]]
[[Kategori:Penghalang alfa-1]]
[[Kategori:Penghalang alfa-2]]
[[Kategori:Antagonis reseptor H1]]
[[Kategori:Eter]]
[[Kategori:Modulator aktivitas dopamin-serotonin]]
[[Kategori:Tetrahidrokuinolina]]
[[Kategori:Obat yang dikembangkan oleh Bristol Myers Squibb]]
[[Kategori:Otsuka Pharmaceutical]]

Revisi terkini sejak 21 Oktober 2024 03.54

Aripiprazol
Structural formula of aripiprazole
Ball-and-stick model of the aripiprazole molecule
Nama sistematis (IUPAC)
7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
Data klinis
Nama dagang Abilify
AHFS/Drugs.com monograph
MedlinePlus a603012
Data lisensi EMA:Aripiprex pranala, US FDA:link
Kat. kehamilan B3(AU) C(US)
Status hukum Harus dengan resep dokter (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US)
Rute Oral (via tablet, tablet orodispersable, dan sirup); intramuskular (termasuk sebagai depot)
Data farmakokinetik
Bioavailabilitas 87%[1]

[2][3][4]

Ikatan protein >99%[1][2][3][4]
Metabolisme Hepatik (hati; terutama via CYP3A4 dan CYP2D6[1][2][3][4])
Waktu paruh 75 jam (metabolit aktif adalah 94 jam)[1][2][3][4]
Ekskresi Ginjal (27%; <1% tidak berubah), Tinja (60%; 18% tidak berubah)[1][2][3][4]
Pengenal
Nomor CAS 129722-12-9 YaY
Kode ATC N05AX12
PubChem CID 60795
Ligan IUPHAR 34
DrugBank DB01238
ChemSpider 54790 YaY
UNII 82VFR53I78 YaY
KEGG D01164 YaY
ChEBI CHEBI:31236 YaY
ChEMBL CHEMBL1112 YaY
Data kimia
Rumus C23H27Cl2N3O2 
Massa mol. 448.385 g/mol
SMILES eMolecules & PubChem

  • InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) YaY
    Key:CEUORZQYGODEFX-UHFFFAOYSA-N YaY

Aripiprazol, dijual dengan nama merek Abilify adalah antipsikotik atipikal. Obat dianjurkan dan terutama digunakan dalam pengobatan skizofrenia dan gangguan bipolar.[5] Kegunaan lain termasuk sebagai terapi tambahan pada penyakit depresi, gangguan tic, dan iritabilitas yang berhubungan dengan autisme.[6] Menurut review Cochrane, bukti bentuk oral pada skizofrenia tidak cukup untuk menentukan efek pada fungsi umum.[7] Selain itu, karena banyak orang putus obat selama percobaan sebelum mereka selesai, keseluruhan kekuatan kesimpulan adalah rendah.[7]

Referensi

[sunting | sunting sumber]
  1. ^ a b c d e "Product Information for ABILIFYTM Aripiprazole Tablets & Orally Disintegrating Tablets". TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. Diakses tanggal 22 October 2013. 
  2. ^ a b c d e "ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]". DailyMed. Otsuka America Pharmaceutical, Inc. April 2013. Diakses tanggal 22 October 2013. 
  3. ^ a b c d e "Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Diarsipkan dari versi asli tanggal 2016-03-04. Diakses tanggal 22 October 2013. 
  4. ^ a b c d e "ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF). European Medicines Agency. Otsuka Pharmaceutical Europe Ltd. Diakses tanggal 22 October 2013. 
  5. ^ "abilify". The American Society of Health-System Pharmacists. Diakses tanggal 3 April 2011. 
  6. ^ http://www.webmd.com/drugs/drug-64439-Abilify+Oral.aspx?drugid=64439&drugname=Abilify+Oral&source=1
  7. ^ a b Belgamwar RB, El-Sayeh HG (Aug 10, 2011). "Aripiprazole versus placebo for schizophrenia". The Cochrane database of systematic reviews (8): CD006622. doi:10.1002/14651858.CD006622.pub2. PMID 21833956. 
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