P53: Perbedaan antara revisi
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| accessdate = 2010-11-19 |
| accessdate = 2010-11-19 |
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| work = Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair |
| work = Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair |
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Rendahnya asupan [[asam folat]] dan [[vitamin B6]] dapat meningkatkan risiko mutasi genetik pada p53 dan menginduksi [[kanker usus besar]].<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634965 |
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| title = FOLATE AND VITAMIN B6 INTAKE AND RISK OF COLON CANCER IN RELATION TO P53 MUTATIONAL STATUS |
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| accessdate = 2010-12-12 |
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| work = Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria and Applied Cancer Research - Institute for Translational Research Vienna (ACR–ITR VIEnna), Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer Institute; Eva S. Schernhammer, MD, DrPH, Shuji Ogino, MD, PhD, dan Charles S. Fuchs, MD, MPH |
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Revisi per 12 Desember 2010 01.09
p53 (bahasa Inggris: protein 53, p53) adalah faktor transkripsi yang mendapat julukan dalam bahasa Inggris sebagai "the guardian of the genome", atau "guardian angel gene", dan "master watchman" karena peran protein tersebut dalam menjaga sel dari mutasi genetik akibat kerusakan DNA.
p53 memiliki ekspresi yang beragam seperti berbagai fungsi selular, regulasi, apoptosis, replikasi DNA, proliferasi, dll. Dalam kondisi normal, jumlah konsentrasi p53 dalam sitoplasma sangat sedikit dan hanya teraktivasi saat sel mengalami stress.[1]
Rendahnya asupan asam folat dan vitamin B6 dapat meningkatkan risiko mutasi genetik pada p53 dan menginduksi kanker usus besar.[2]
Rujukan
- ^ (Inggris)"Watching the watcher: regulation of p53 by mitochondria". Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair. Diakses tanggal 2010-11-19.
- ^ (Inggris)"FOLATE AND VITAMIN B6 INTAKE AND RISK OF COLON CANCER IN RELATION TO P53 MUTATIONAL STATUS". Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria and Applied Cancer Research - Institute for Translational Research Vienna (ACR–ITR VIEnna), Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer Institute; Eva S. Schernhammer, MD, DrPH, Shuji Ogino, MD, PhD, dan Charles S. Fuchs, MD, MPH. Diakses tanggal 2010-12-12.
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