Glutamin sintetase: Perbedaan antara revisi
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{{enzyme |
{{infobox enzyme |
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| Name = glutamate—ammonia ligase |
| Name = glutamate—ammonia ligase |
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| EC_number = 6.3.1.2 |
| EC_number = 6.3.1.2 |
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Revisi per 28 April 2016 06.05
| glutamate—ammonia ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange; ADP is pink; phosphinothricin is blue.[1] | |||||||||
| Pengidentifikasi | |||||||||
| Nomor EC | 6.3.1.2 | ||||||||
| Nomor CAS | 9023-70-5 | ||||||||
| Basis data | |||||||||
| IntEnz | tinjauan IntEnz | ||||||||
| BRENDA | entri BRENDA | ||||||||
| ExPASy | tinjauan NiceZyme | ||||||||
| KEGG | entri KEGG | ||||||||
| MetaCyc | jalur metabolik | ||||||||
| PRIAM | profil | ||||||||
| Struktur PDB | RCSB PDB PDBe PDBsum | ||||||||
| Ontologi Gen | AmiGO / EGO | ||||||||
| |||||||||
| Glutamine synthetase, beta-Grasp domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikasi | |||||||||
| Simbol | Gln-synt_N | ||||||||
| Pfam | PF03951 | ||||||||
| InterPro | IPR008147 | ||||||||
| PROSITE | PDOC00162 | ||||||||
| SCOP | 2gls | ||||||||
| SUPERFAMILY | 2gls | ||||||||
| |||||||||
| Glutamine synthetase, catalytic domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 12-subunit enzyme glutamine synthetase from Salmonella typhimurium.[2] | |||||||||
| Identifikasi | |||||||||
| Simbol | Gln-synt_C | ||||||||
| Pfam | PF00120 | ||||||||
| Klan Pfam | CL0286 | ||||||||
| InterPro | IPR008146 | ||||||||
| PROSITE | PDOC00162 | ||||||||
| SCOP | 2gls | ||||||||
| SUPERFAMILY | 2gls | ||||||||
| |||||||||
| glutamate-ammonia ligase (glutamine synthetase) | |||||||
|---|---|---|---|---|---|---|---|
| Pengidentifikasi | |||||||
| Simbol | GLUL | ||||||
| Simbol alternatif | GLNS | ||||||
| Gen NCBI | 2752 | ||||||
| HGNC | 4341 | ||||||
| OMIM | 138290 | ||||||
| PDB | 2qc8 | ||||||
| RefSeq | NM_002065 | ||||||
| UniProt | P15104 | ||||||
| Data lain | |||||||
| Nomor EC | 6.3.1.2 | ||||||
| Lokus | Chr. 1 q31 | ||||||
| |||||||
Glutamin sintetase (GS) (EC 6.3.1.2)[3] adalah enzim yang memainkan peran penting dalam metabolisme nitrogen dengan mengkatalisis kondensasi glutamat dan amonia untuk membentuk glutamin:
Glutamat + ATP + NH3 → Glutamin + ADP + fosfat
Referensi
- ^ PDB: 1FPY; Gill HS, Eisenberg D (February 2001). "The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition". Biochemistry. 40 (7): 1903–12. doi:10.1021/bi002438h. PMID 11329256.
- ^ PDB: 2GLS; Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D (October 1989). "Refined atomic model of glutamine synthetase at 3.5 A resolution". J. Biol. Chem. 264 (30): 17681–90. PMID 2572586.
- ^ Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW (1987). "Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO". Cold Spring Harb. Symp. Quant. Biol. 52: 483–90. doi:10.1101/sqb.1987.052.01.055. PMID 2900091.