Simetidin: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
←Membuat halaman berisi '{{Drugbox | Watchedfields = changed | verifiedrevid = 456484490 | IUPAC_name = 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine | image...' Tag: |
Tidak ada ringkasan suntingan |
||
| Baris 9: | Baris 9: | ||
| pronounce = {{IPAc-en|s|ɨ|ˈ|m|ɛ|t|ɨ|d|iː|n}} or {{IPAc-en|s|aɪ|ˈ|m|ɛ|t|ɨ|d|iː|n}} |
| pronounce = {{IPAc-en|s|ɨ|ˈ|m|ɛ|t|ɨ|d|iː|n}} or {{IPAc-en|s|aɪ|ˈ|m|ɛ|t|ɨ|d|iː|n}} |
||
| tradename = Tagamet |
| tradename = Tagamet |
||
| synonyms = cimetidine hydrochloride<br> SKF-92334<ref name="Elks2014">{{cite book | first = J. | last = Elks | name-list-format = vanc | title = The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | url = https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA275 | date = 14 November 2014 | publisher = Springer | isbn = 978-1-4757-2085-3 | pages = 275– }}</ref> |
|||
| synonyms = cimetidine hydrochloride<br> SKF-92334<ref name="Elks2014" /> |
|||
| Drugs.com = {{drugs.com|monograph|cimetidine}} |
| Drugs.com = {{drugs.com|monograph|cimetidine}} |
||
| MedlinePlus = a682256 |
| MedlinePlus = a682256 |
||
Revisi per 24 November 2016 03.56
| |
|---|---|
| |
| Nama sistematis (IUPAC) | |
| 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine | |
| Data klinis | |
| Nama dagang | Tagamet |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682256 |
| Data lisensi | US FDA:link |
| Kat. kehamilan | B1(AU) B(US) |
| Status hukum | Harus dengan resep dokter (S4) (AU) POM (UK) ? (US) |
| Rute | Oral, parenteral |
| Data farmakokinetik | |
| Bioavailabilitas | 60–70% |
| Ikatan protein | 15–20% |
| Metabolisme | Hepatic |
| Waktu paruh | 2 hours[1] |
| Ekskresi | Renal |
| Pengenal | |
| Nomor CAS | 51481-61-9 
|
| Kode ATC | A02BA01 |
| PubChem | CID 2756 |
| Ligan IUPHAR | 1231 |
| DrugBank | DB00501 |
| ChemSpider | 2654
|
| UNII | 80061L1WGD
|
| KEGG | D00295
|
| ChEBI | CHEBI:3699
|
| ChEMBL | CHEMBL30
|
| Sinonim | cimetidine hydrochloride SKF-92334[2] |
| Data kimia | |
| Rumus | C10H16N6S |
| Massa mol. | 252.34 g/mol |
| SMILES | eMolecules & PubChem |
| |
Simetidin adalah obat anggota kelas penghambat H2 (antagonis H2). Obat ini bekerja dengan mengurangi jumlah asam di dalam lambung.
Penggunaan medis
Beberapa kondisi yang dapat ditangani oleh simetidin adalah tukak lambung dan usus halus, sakit maag, gangguan pencernaan dan penyakit refluks gastroesofagus. Obat juga dapat mengobati iritasi pada lambung yang disebabkan oleh penggunaan obat anti-inflamasi nonsteroid (OAINS).
Farmakologi
Mekanisme aksi
Referensi
- ^ Vallerand AH, Sanoski CA, Deglin JH (25 May 2016). Davis's Drug Guide for Nurses. F.A. Davis. hlm. 636–. ISBN 978-0-8036-5779-3.
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 275–. ISBN 978-1-4757-2085-3.