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Artikel baru tentang topik farmasi yang masih memerlukan tambahan dan pengembangan. Artikel ini merupakan terjemahan wikipedia bahasa Inggris masih perlu ditinjau ulang juga disesuaikan dengan padanan bahasa Indonesia. Saya memasukkan kategori obat karena, artikel ini mudah terorganisir sebagai obat
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<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=Rx-only|DailyMedID=Celecoxib|licence_US=Celebrex|licence_EU=<!-- EMA uses INN (or special INN_EMA) -->
<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=Rx-only|DailyMedID=Celecoxib|licence_US=Celebrex|licence_EU=<!-- EMA uses INN (or special INN_EMA) -->


<!-- Pharmacokinetic data -->|bioavailability=Unknown<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>|protein_bound=97% (mainly to [[serum albumin]])<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>|metabolism=Liver (mainly [[CYP2C9]])<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>|metabolites=|elimination_half-life=7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>|excretion=Faeces (57%), urine (27%)<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>
<!-- Pharmacokinetic data -->|bioavailability=Unknown<ref name=drugs>{{cite journal | vauthors = McCormack PL | title = Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis | journal = Drugs | volume = 71 | issue = 18 | pages = 2457–89 | date = December 2011 | pmid = 22141388 | doi = 10.2165/11208240-000000000-00000 }}</ref>|protein_bound=97% (mainly to [[serum albumin]])<ref name=drugs />|metabolism=Liver (mainly [[CYP2C9]])<ref name=drugs />|metabolites=|elimination_half-life=7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)<ref name=drugs />|excretion=Faeces (57%), urine (27%)<ref name=drugs />


<!-- Chemical and physical data -->|C=17|F=3|H=14|N=3|O=2|S=1|smiles=O=S(=O)(c3ccc(n1nc(cc1c2ccc(cc2)C)C(F)(F)F)cc3)N|StdInChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChI_comment=|StdInChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|molecular_weight=381.373|density=|melting_point=|melting_high=|melting_notes=|boiling_point=|boiling_notes=|solubility=|specific_rotation=}}
<!-- Chemical and physical data -->|C=17|F=3|H=14|N=3|O=2|S=1|smiles=O=S(=O)(c3ccc(n1nc(cc1c2ccc(cc2)C)C(F)(F)F)cc3)N|StdInChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChI_comment=|StdInChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|molecular_weight=381.373|density=|melting_point=|melting_high=|melting_notes=|boiling_point=|boiling_notes=|solubility=|specific_rotation=}}


'''Celecoxib''' adalah obat penghambat COX-2 dan [[Obat antiinflamasi nonsteroid|obat anti inflamasi nonsteroid]] (NSAID). <ref name="AHFS2019">{{Cite web|title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live |access-date=5 May 2020}}</ref> Obat ini dipergunakan untuk mengatasi [[nyeri]] dan [[Radang|peradangan]] pada [[Osteoartritis|osteoarthritis]], [[Nyeri|nyeri akut]] pada orang dewasa, [[Rheumatoid Arthritis|rheumatoid arthritis]], [[ankilosing spodilitis]], dan [[dismenorea]]. <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref> Obat ini juga bisa dipergunakan untuk mengurangi risiko adenoma kolorektal pada penderita dengan poliposis adenomatosa familial . <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref> Rute pemberian obat melalui oral . <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref> Efek terapi akan terlihat dalam waktu 1jam. <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref>
'''Celecoxib''' adalah obat penghambat COX-2 dan [[Obat antiinflamasi nonsteroid|obat anti inflamasi nonsteroid]] (NSAID). <ref name="AHFS2019">{{Cite web|title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live |access-date=5 May 2020}}</ref> Obat ini dipergunakan untuk mengatasi [[nyeri]] dan [[Radang|peradangan]] pada [[Osteoartritis|osteoarthritis]], [[Nyeri|nyeri akut]] pada orang dewasa, [[Rheumatoid Arthritis|rheumatoid arthritis]], [[ankilosing spodilitis]], dan [[dismenorea]]. <ref name="AHFS2019" /> Obat ini juga bisa dipergunakan untuk mengurangi risiko adenoma kolorektal pada penderita dengan poliposis adenomatosa familial . <ref name="AHFS2019" /> Rute pemberian obat melalui oral . <ref name="AHFS2019" /> Efek terapi akan terlihat dalam waktu 1jam. <ref name="AHFS2019" />


Kejadian efek samping yang umum bisa terjadi seperti [[mulas]], mual, dan [[diare]] . <ref name="AHFS2019">{{Cite web|title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live |access-date=5 May 2020}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/celecoxib.html "Celecoxib Monograph for Professionals"]. ''Drugs.com''. American Society of Health-System Pharmacists. 11 November 2019. [https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html Archived] from the original on 20 May 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite></ref> Efek samping serius yang bisa terjadi yakni [[serangan jantung]], [[Strok|stroke]], perforasi saluran cerna, [[Pendarahan gastrointestinal|perdarahan gastrointestinal]], gagal ginjal, dan [[anafilaksis]] . <ref name="Coxib2013">{{Cite journal|date=August 2013|title=Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials|journal=Lancet|volume=382|issue=9894|pages=769–79|doi=10.1016/S0140-6736(13)60900-9|pmc=3778977|pmid=23726390|vauthors=Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C}}</ref> <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref> Obat ini tidak direkomendasikan untuk individu yang memiliki risiko tinggi terkena penyakit jantung. <ref name="AHA2007">{{Cite journal|date=March 2007|title=Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association|journal=Circulation|volume=115|issue=12|pages=1634–42|doi=10.1161/circulationaha.106.181424|pmid=17325246|vauthors=Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA}}</ref> <ref name="Consumer2012">{{Cite web|date=August 2009|title=Should you still take Celebrex?|url=http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm|website=[[Consumer Reports]]|archive-url=https://web.archive.org/web/20151218111927/http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm|archive-date=18 December 2015|access-date=27 December 2015|url-status=live}}</ref> Risikonya obat ini sama dengan golongan NSAID lain, seperti [[ibuprofen]] dan [[Naproksen|naproxen]] . <ref name="NPR2018">{{Cite news|last=Stein|first=Rob|date=25 April 2018|title=FDA Panel Affirms Safety Of Painkiller Celebrex|url=https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex|publisher=[[NPR]]|archive-url=https://web.archive.org/web/20180520123906/https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex|archive-date=20 May 2018|access-date=19 May 2018|url-status=live}}</ref> Untuk pengguna ibu [[Kehamilan|hamil]] atau ibu [[menyusui]] tidak direkomendasikan untuk digunakan. <ref name="AHFS2019">{{cite web |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |date=11 November 2019 |accessdate=5 May 2020 |archive-date=20 May 2019 |archive-url=https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html |url-status=live }}</ref> <ref name="Drugs.com pregnancy">{{Cite web| title=Celecoxib (Celebrex) Use During Pregnancy | website=Drugs.com | date=4 May 2020 | url=https://www.drugs.com/pregnancy/celecoxib.html | access-date=5 May 2020 | archive-date=25 January 2021 | archive-url=https://web.archive.org/web/20210125072333/https://www.drugs.com/pregnancy/celecoxib.html | url-status=live }}</ref>
Kejadian efek samping yang umum bisa terjadi seperti [[mulas]], mual, dan [[diare]] . <ref name="AHFS2019" /> Efek samping serius yang bisa terjadi yakni [[serangan jantung]], [[Strok|stroke]], perforasi saluran cerna, [[Pendarahan gastrointestinal|perdarahan gastrointestinal]], gagal ginjal, dan [[anafilaksis]] . <ref name="Coxib2013">{{Cite journal|date=August 2013|title=Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials|journal=Lancet|volume=382|issue=9894|pages=769–79|doi=10.1016/S0140-6736(13)60900-9|pmc=3778977|pmid=23726390|vauthors=Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C}}</ref> <ref name="AHFS2019" /> Obat ini tidak direkomendasikan untuk individu yang memiliki risiko tinggi terkena penyakit jantung. <ref name="AHA2007">{{Cite journal|date=March 2007|title=Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association|journal=Circulation|volume=115|issue=12|pages=1634–42|doi=10.1161/circulationaha.106.181424|pmid=17325246|vauthors=Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA}}</ref> <ref name="Consumer2012">{{Cite web|date=August 2009|title=Should you still take Celebrex?|url=http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm|website=[[Consumer Reports]]|archive-url=https://web.archive.org/web/20151218111927/http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm|archive-date=18 December 2015|access-date=27 December 2015|url-status=live}}</ref> Risikonya obat ini sama dengan golongan NSAID lain, seperti [[ibuprofen]] dan [[Naproksen|naproxen]] . <ref name="NPR2018">{{Cite news|last=Stein|first=Rob|date=25 April 2018|title=FDA Panel Affirms Safety Of Painkiller Celebrex|url=https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex|publisher=[[NPR]]|archive-url=https://web.archive.org/web/20180520123906/https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex|archive-date=20 May 2018|access-date=19 May 2018|url-status=live}}</ref> Untuk pengguna ibu [[Kehamilan|hamil]] atau ibu [[menyusui]] tidak direkomendasikan untuk digunakan. <ref name="AHFS2019" /> <ref name="Drugs.com pregnancy">{{Cite web| title=Celecoxib (Celebrex) Use During Pregnancy | website=Drugs.com | date=4 May 2020 | url=https://www.drugs.com/pregnancy/celecoxib.html | access-date=5 May 2020 | archive-date=25 January 2021 | archive-url=https://web.archive.org/web/20210125072333/https://www.drugs.com/pregnancy/celecoxib.html | url-status=live }}</ref>


== Referensi ==
== Referensi ==

Revisi per 10 Februari 2024 17.10

Skeletal formula of celecoxib
Space-filling model of the celecoxib molecule
Nama sistematis (IUPAC)
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Data klinis
Nama dagang Celebrex, Onsenal, Elyxyb, others
AHFS/Drugs.com monograph
MedlinePlus a699022
Data lisensi US Daily Med:pranala
Kat. kehamilan B3(AU) C(US)
Status hukum Harus dengan resep dokter (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US) ℞ Preskripsi saja
Rute By mouth
Data farmakokinetik
Bioavailabilitas Unknown[1]
Ikatan protein 97% (mainly to serum albumin)[1]
Metabolisme Liver (mainly CYP2C9)[1]
Waktu paruh 7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)[1]
Ekskresi Faeces (57%), urine (27%)[1]
Pengenal
Kode ATC ?
Data kimia
Rumus C17H14F3N3O2S 
Massa mol. 381.373
SMILES eMolecules & PubChem

  • InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) YaY
    Key:RZEKVGVHFLEQIL-UHFFFAOYSA-N YaY

Celecoxib adalah obat penghambat COX-2 dan obat anti inflamasi nonsteroid (NSAID). [2] Obat ini dipergunakan untuk mengatasi nyeri dan peradangan pada osteoarthritis, nyeri akut pada orang dewasa, rheumatoid arthritis, ankilosing spodilitis, dan dismenorea. [2] Obat ini juga bisa dipergunakan untuk mengurangi risiko adenoma kolorektal pada penderita dengan poliposis adenomatosa familial . [2] Rute pemberian obat melalui oral . [2] Efek terapi akan terlihat dalam waktu 1jam. [2]

Kejadian efek samping yang umum bisa terjadi seperti mulas, mual, dan diare . [2] Efek samping serius yang bisa terjadi yakni serangan jantung, stroke, perforasi saluran cerna, perdarahan gastrointestinal, gagal ginjal, dan anafilaksis . [3] [2] Obat ini tidak direkomendasikan untuk individu yang memiliki risiko tinggi terkena penyakit jantung. [4] [5] Risikonya obat ini sama dengan golongan NSAID lain, seperti ibuprofen dan naproxen . [6] Untuk pengguna ibu hamil atau ibu menyusui tidak direkomendasikan untuk digunakan. [2] [7]

Referensi

  1. ^ a b c d e McCormack PL (December 2011). "Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis". Drugs. 71 (18): 2457–89. doi:10.2165/11208240-000000000-00000. PMID 22141388. 
  2. ^ a b c d e f g h "Celecoxib Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. 11 November 2019. Diarsipkan dari versi asli tanggal 20 May 2019. Diakses tanggal 5 May 2020. 
  3. ^ Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C (August 2013). "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials". Lancet. 382 (9894): 769–79. doi:10.1016/S0140-6736(13)60900-9. PMC 3778977 alt=Dapat diakses gratis. PMID 23726390. 
  4. ^ Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (March 2007). "Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association". Circulation. 115 (12): 1634–42. doi:10.1161/circulationaha.106.181424. PMID 17325246. 
  5. ^ "Should you still take Celebrex?". Consumer Reports. August 2009. Diarsipkan dari versi asli tanggal 18 December 2015. Diakses tanggal 27 December 2015. 
  6. ^ Stein, Rob (25 April 2018). "FDA Panel Affirms Safety Of Painkiller Celebrex". NPR. Diarsipkan dari versi asli tanggal 20 May 2018. Diakses tanggal 19 May 2018. 
  7. ^ "Celecoxib (Celebrex) Use During Pregnancy". Drugs.com. 4 May 2020. Diarsipkan dari versi asli tanggal 25 January 2021. Diakses tanggal 5 May 2020. 
Ikon rintisan

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