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Muhammad Anas Sidik (bicara | kontrib)
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←Membuat halaman berisi ''''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati mabuk gerak dan mual. Dimenhidrinat adalah garam teoklat yang terdiri dari difenhidramin (turunan etanolamina) dan 8-kloroteofilin (turunan teofilin terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Se...'
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Muhammad Anas Sidik (bicara | kontrib)
19.361 suntingan
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Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan
Baris 1: Baris 1:
{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 459441657
| type = combo
| image = Dimenhydrinate.svg
| width = 160
| alt =
| caption =

<!-- Combo data -->
| component1 = Difenhidramin
| class1 = [[Antihistamin]], [[sedatif]]
| component2 = 8-kloroteofilin
| class2 = [[Stimulan]]
| tradename = Antimo, dramamine, Draminate, Gravol, dll
| Drugs.com = {{drugs.com|monograph|dimenhydrinate}}
| MedlinePlus = a607046
| DailyMedID = Dimenhydrinate
| pregnancy_AU = A
| pregnancy_AU_comment =
| pregnancy_category =
| routes_of_administration = [[Oral (rute pemberian obat)|Oral]], [[rektal]], [[intravaskular]], [[Penyuntikan intraotot|intramuskular]]
| ATCvet =
| ATC_prefix = R06
| ATC_suffix = AA11
| ATC_supplemental = combinations {{ATC|R06|AA61}}

<!-- Pharmacokinetic data -->
| bioavailability =
| protein_bound =
| metabolism = [[Liver]]
| elimination_half-life = 5.5 hours<ref name="oral_sublingual2328304">{{cite journal | vauthors = Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ | title = Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration | journal = Biopharmaceutics & Drug Disposition | volume = 11 | issue = 3 | pages = 185–189 | date = April 1990 | pmid = 2328304 | doi = 10.1002/bdd.2510110302 }}</ref> (diphenhydramine component)
| excretion =
<!-- Legal status -->
| legal_AU = S2
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = [[Over-the-counter drug|OTC]]
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = OTC
| legal_US_comment =
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 523-87-5
| CAS_supplemental =
| PubChem = 10660
| IUPHAR_ligand =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00985
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10210
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = JB937PER5C
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00520
| ChEBI = 94848
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200406
| NIAID_ChemDB =
| PDB_ligand =
| synonyms =
}}

'''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati [[mabuk gerak]] dan [[mual]]. Dimenhidrinat adalah garam teoklat yang terdiri dari [[difenhidramin]] (turunan [[etanolamina]]) dan 8-kloroteofilin (turunan [[teofilin]] terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Second |chapter=34 - Pharmacology of Postoperative Nausea and Vomiting |publisher=[[Elsevier Inc.]] |year=2019 |isbn=978-0-323-48110-6 | veditors = Hemmings Jr HC, Talmage ED |pages=671–692 |doi=10.1016/B978-0-323-48110-6.00034-X |s2cid=81387334 | vauthors = Zabirowicz ES, Gan TJ }}</ref> Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.<ref name="Newman 2012">{{cite web | vauthors = Newman A |title=New Dramamine Ads Take Aim at Summer Vacationers |website=The New York Times |date=21 June 2012 |url=https://www.nytimes.com/2012/06/21/business/media/new-dramamine-ads-take-aim-at-summer-vacationers.html |access-date=26 June 2023}}</ref><ref name="Grauer 2019">{{cite web | vauthors = Grauer N |title=Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness |website=Johns Hopkins Medicine |date=12 February 2019 |url=https://www.hopkinsmedicine.org/news/articles/hopkins-history-moments-3 |access-date=27 June 2023}}</ref>
'''Dimenhidrinat''' merupakan obat bebas yang digunakan untuk mengobati [[mabuk gerak]] dan [[mual]]. Dimenhidrinat adalah garam teoklat yang terdiri dari [[difenhidramin]] (turunan [[etanolamina]]) dan 8-kloroteofilin (turunan [[teofilin]] terklorinasi) dengan perbandingan 1:1.<ref name = "Hemmings_2019">{{Cite book |chapter-url=https://www.sciencedirect.com/science/article/pii/B978032348110600034X |title=Pharmacology and Physiology for Anesthesia | edition = Second |chapter=34 - Pharmacology of Postoperative Nausea and Vomiting |publisher=[[Elsevier Inc.]] |year=2019 |isbn=978-0-323-48110-6 | veditors = Hemmings Jr HC, Talmage ED |pages=671–692 |doi=10.1016/B978-0-323-48110-6.00034-X |s2cid=81387334 | vauthors = Zabirowicz ES, Gan TJ }}</ref> Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.<ref name="Newman 2012">{{cite web | vauthors = Newman A |title=New Dramamine Ads Take Aim at Summer Vacationers |website=The New York Times |date=21 June 2012 |url=https://www.nytimes.com/2012/06/21/business/media/new-dramamine-ads-take-aim-at-summer-vacationers.html |access-date=26 June 2023}}</ref><ref name="Grauer 2019">{{cite web | vauthors = Grauer N |title=Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness |website=Johns Hopkins Medicine |date=12 February 2019 |url=https://www.hopkinsmedicine.org/news/articles/hopkins-history-moments-3 |access-date=27 June 2023}}</ref>


Revisi per 22 Mei 2024 22.34

Dimenhidrinat
Kombinasi
Difenhidramin Antihistamin, sedatif
8-kloroteofilin Stimulan
Data klinis
Nama dagang Antimo, dramamine, Draminate, Gravol, dll
AHFS/Drugs.com monograph
MedlinePlus a607046
Data lisensi US Daily Med:pranala
Kat. kehamilan A(AU)
Status hukum Apotek saja (S2) (AU) ? (CA) OTC (US)
Rute Oral, rektal, intravaskular, intramuskular
Pengenal
Nomor CAS 523-87-5 YaY
Kode ATC R06AA11 combinations R06AA61
PubChem CID 10660
DrugBank DB00985
ChemSpider 10210 YaY
UNII JB937PER5C YaY
KEGG D00520 YaY
ChEBI CHEBI:94848
ChEMBL CHEMBL1200406 N

Dimenhidrinat merupakan obat bebas yang digunakan untuk mengobati mabuk gerak dan mual. Dimenhidrinat adalah garam teoklat yang terdiri dari difenhidramin (turunan etanolamina) dan 8-kloroteofilin (turunan teofilin terklorinasi) dengan perbandingan 1:1.[1] Dimenhidrinat diperkenalkan ke pasar oleh G.D. Searle pada tahun 1949.[2][3]

Referensi

  1. ^ Zabirowicz ES, Gan TJ (2019). "34 - Pharmacology of Postoperative Nausea and Vomiting". Dalam Hemmings Jr HC, Talmage ED. Pharmacology and Physiology for Anesthesia (edisi ke-Second). Elsevier Inc. hlm. 671–692. doi:10.1016/B978-0-323-48110-6.00034-X. ISBN 978-0-323-48110-6. 
  2. ^ Newman A (21 June 2012). "New Dramamine Ads Take Aim at Summer Vacationers". The New York Times. Diakses tanggal 26 June 2023. 
  3. ^ Grauer N (12 February 2019). "Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness". Johns Hopkins Medicine. Diakses tanggal 27 June 2023. 
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