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←Membuat halaman berisi '{{Drugbox | verifiedrevid = 477164914 | IUPAC_name = 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5''H''-benzo[5,6]cyclohepta[1,2-''b'']pyridine | image = Azatadine.svg <!--Clinical data--> | tradename = Optimine | Drugs.com = {{drugs.com|CONS|azatadine}} | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = B | legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> | legal_UK = <!-- GSL / P / POM / CD --> | legal_US = <!--Identifiers--> | IUPHAR_liga...'
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{{Drugbox
{{Drugbox
| verifiedrevid = 477164914
| verifiedrevid = 477164914
| IUPAC_name = 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5''H''-benzo[5,6]cyclohepta[1,2-''b'']pyridine
| IUPAC_name = 11-(1-Metilpiperidin-4-ilidena)-6,11-dihidro-5''H''-benzo[5,6]siklohepta[1,2-''b'']piridina
| image = Azatadine.svg
| image = Azatadine.svg
<!--Clinical data-->
<!--Clinical data-->
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}}
}}


'''Azatadine''' adalah obat antihistamin dan antikolinergik generasi pertama yang disintesis pada tahun 1963 oleh Schering-Plough, bekas perusahaan farmasi Amerika.[1][2]
'''Azatadin''' adalah obat [[antihistamin]] dan [[antikolinergik]] generasi pertama yang disintesis pada tahun 1963 oleh Schering-Plough, bekas perusahaan farmasi Amerika Serikat.<ref>{{cite journal | vauthors = Katelaris C | title = Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis | journal = Asian Pacific Journal of Allergy and Immunology | volume = 8 | issue = 2 | pages = 103–7 | date = December 1990 | pmid = 1982614 }}</ref><ref>{{cite journal | vauthors = Small P, Barrett D, Biskin N | title = Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation | journal = Annals of Allergy | volume = 64 | issue = 2 Pt 1 | pages = 129–31 | date = February 1990 | pmid = 1968324 }}</ref>

Obat ini dipatenkan pada tahun 1967.<ref>{{cite patent | title = Azatadine | inventor = Villani FJ, Caldwell W | country = US | number = 3326924 | gdate = 1967 }}</ref> Obat ini telah digantikan oleh [[loratadin]] dan [[desloratadin]].<ref>{{cite book | vauthors = Horak F | chapter = Antialergic and Vasoactive Drugs for Allergic Rhinitis. Chapter 4 | title = Allergy Frontiers:Therapy and Prevention. | volume = 5 | veditors = Pawankar R, Holgate ST, Rosenwasser LJ | publisher = Springer Science & Business Media | date = 2010 | isbn = 9784431993629 }}</ref>{{rp|53}}  dan persetujuan pemasarannya telah banyak ditarik.<ref>{{cite web | work = Drugs.com | url = https://www.drugs.com/mtm/azatadine.html | title = Azatadine }}</ref><ref>{{cite web | work = Federal Register 70 FR 10651 | date = 2005 | url = https://www.federalregister.gov/articles/2005/03/04/05-4158/hospira-inc-et-al-withdrawal-of-approval-of-76-new-drug-applications-and-60-abbreviated-new-drug | author = Food and Drug Administration | title = Docket No.2005N-0058: Hospira, Inc. et al.; Withdrawal of Approval of 76 New Drug Applications and 60 Abbreviated New Drug Applications }} </ref><ref>{{cite web | work = Federal Register 72 FR 8184 | date = 2007 | url = http://www.gpo.gov/fdsys/pkg/FR-2007-02-23/html/E7-3043.htm | author = Food and Drug Administration | title = Docket No. 2004P-0262: Withdrawal of Approval of 128 Suitability Petitions }}</ref><ref>{{cite web | work = Department of Economic and Social Affairs of the United Nations Secretariat | url = https://www.un.org/esa/coordination/CL12.pdf | title = Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals | publisher = United Nations | location = New York | date = 2005 }}</ref>{{rp|290}}<ref>{{cite web | work = FDA | url = https://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/ucm283497.htm | title = OGD Suitability Tracking Report (Sorted by Drug Name) }}</ref>


Obat ini dipatenkan pada tahun 1967.[3] Obat ini telah digantikan oleh loratadine dan desloratadine.[4]: 53  dan persetujuan pemasarannya telah banyak ditarik.[5][6][7][8]: 290 [9]
== Referensi ==
== Referensi ==
{{Reflist}}
{{Reflist}}

Revisi per 15 Oktober 2024 15.35

Azatadin
Nama sistematis (IUPAC)
11-(1-Metilpiperidin-4-ilidena)-6,11-dihidro-5H-benzo[5,6]siklohepta[1,2-b]piridina
Data klinis
Nama dagang Optimine
AHFS/Drugs.com Micromedex Detailed Consumer Information
Kat. kehamilan B(US)
Status hukum ?
Pengenal
Nomor CAS 3964-81-6 YaY
Kode ATC R06AX09
PubChem CID 19861
Ligan IUPHAR 7119
DrugBank DB00719
ChemSpider 18709 YaY
UNII 94Z39NID6C YaY
KEGG D07482 YaY
ChEBI CHEBI:2946 YaY
ChEMBL CHEMBL946 YaY
Data kimia
Rumus C20H22N2 
SMILES eMolecules & PubChem

  • InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3 YaY
    Key:SEBMTIQKRHYNIT-UHFFFAOYSA-N YaY

Azatadin adalah obat antihistamin dan antikolinergik generasi pertama yang disintesis pada tahun 1963 oleh Schering-Plough, bekas perusahaan farmasi Amerika Serikat.[1][2]

Obat ini dipatenkan pada tahun 1967.[3] Obat ini telah digantikan oleh loratadin dan desloratadin.[4]:53  dan persetujuan pemasarannya telah banyak ditarik.[5][6][7][8]:290[9]

Referensi

  1. ^ Katelaris C (December 1990). "Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis". Asian Pacific Journal of Allergy and Immunology. 8 (2): 103–7. PMID 1982614. 
  2. ^ Small P, Barrett D, Biskin N (February 1990). "Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation". Annals of Allergy. 64 (2 Pt 1): 129–31. PMID 1968324. 
  3. ^ US 3326924, Villani FJ, Caldwell W, "Azatadine", dikeluarkan tanggal 1967 
  4. ^ Horak F (2010). "Antialergic and Vasoactive Drugs for Allergic Rhinitis. Chapter 4". Dalam Pawankar R, Holgate ST, Rosenwasser LJ. Allergy Frontiers:Therapy and Prevention. 5. Springer Science & Business Media. ISBN 9784431993629. 
  5. ^ "Azatadine". Drugs.com. 
  6. ^ Food and Drug Administration (2005). "Docket No.2005N-0058: Hospira, Inc. et al.; Withdrawal of Approval of 76 New Drug Applications and 60 Abbreviated New Drug Applications". Federal Register 70 FR 10651. 
  7. ^ Food and Drug Administration (2007). "Docket No. 2004P-0262: Withdrawal of Approval of 128 Suitability Petitions". Federal Register 72 FR 8184. 
  8. ^ "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005. 
  9. ^ "OGD Suitability Tracking Report (Sorted by Drug Name)". FDA. 
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