Kurkumin: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
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| work = The Institute of Gastroenterology and Liver Disease; Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A. |
| work = The Institute of Gastroenterology and Liver Disease; Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A. |
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* melindungi [[pankreas]] dari akibat rasio [[sitokina]] yang berlebihan,<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/18695642 |
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| title = Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo |
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| accessdate = 2010-06-30 |
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| work = Tissue Engineering and Banking Laboratory, National Centre for Cell Science; Kanitkar M, Gokhale K, Galande S, Bhonde RR. |
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}}</ref> bahkan setelah [[transplantasi]],<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/19188863 |
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| title = Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation |
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| accessdate = 2010-06-30 |
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| work = Diabetes Institute for Immunology and Transplantation, University of Minnesota; Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S. |
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}}</ref> serta menurunkan resistansi terhadap [[insulin]] dan [[leptin]]<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/19176142 |
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| title = [The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin] |
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| accessdate = 2010-06-30 |
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| work = Department of Public Health, Xi'an Jiaotong University School of Medicine; Yu Y, Hu SK, Yan H. |
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}}</ref> |
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* melindungi [[sel Leydig]] dari pengaruh [[alkohol]].<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/18971866 |
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| title = Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration |
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| accessdate = 2010-06-30 |
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| work = Department of Human Morphology and Applied Biology. Faculty of Medicine and Surgery, University of Pisa; Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruffoli R. |
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Revisi per 30 Juni 2010 03.58
Kurkumin (bahasa Inggris: diferuloylmethane adalah senyawa aktif yang ditemukan pada kunir, berupa polifenol dengan rumus kimia C21H20O6. Kurkumin memiliki dua bentuk tautomer: keton dan enol. Struktur keton lebih dominan dalam bentuk padat, sedangkan struktur enol ditemukan dalam bentuk cairan. Senyawa turunan kurkumin disebut kurkuminoid, yang hanya terdapat dua macam, yaitu desmetoksikurkumin dan bis-desmetoksikurkumin.
Kurkumin berinteraksi dengan asam borat menghasilkan senyawa berwarna merah yang disebut rososiania.
Kurkumin dikenal karena sifat antitumor dan antioksidan yang dimilikinya, selain banyak kegunaan medis seperti;
- menghambat dan mengurangi penumpukan plak amiloid-beta pada penderita Alzheimer.[1][2][3][4]
- melindungi hati, antara lain dari hemangioendotelioma,[5] hepatokarsinoma,[6] Hepatitis B.[7]
- melindungi pankreas dari akibat rasio sitokina yang berlebihan,[8] bahkan setelah transplantasi,[9] serta menurunkan resistansi terhadap insulin dan leptin[10]
- melindungi sel Leydig dari pengaruh alkohol.[11]
Rujukan
- ^ (Inggris)"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo". Department of Medicine, UCLA; Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Diakses tanggal 2010-06-27.
- ^ (Inggris)"Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease". Department of Biological and Biomedical Sciences, The Aga Khan University Medical College; Ahmed T, Gilani AH. Diakses tanggal 2010-06-27.
- ^ (Inggris)"Optimized turmeric extracts have potent anti-amyloidogenic effects". Center for Excellence in Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine; Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B Jr, Fink RC, Alberte RS. Diakses tanggal 2010-06-27.
- ^ (Inggris)"Immune defects in Alzheimer's disease: new medications development". Human BioMolecular Research Institute, San Diego; Cashman JR, Ghirmai S, Abel KJ, Fiala M. Diakses tanggal 2010-06-27.
- ^ (Inggris)"Potential response to curcumin in infantile hemangioendothelioma of the liver". University of Oklahoma Health Sciences Center; Hassell LA, Roanh LD. Diakses tanggal 2010-06-30.
- ^ (Inggris)"[Anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1]". Guangdong Pharmaceutical University; Wang W, Zhang B, Chen H, Zhang L. Diakses tanggal 2010-06-30.
- ^ (Inggris)"Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha". The Institute of Gastroenterology and Liver Disease; Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A. Diakses tanggal 2010-06-30.
- ^ (Inggris)"Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo". Tissue Engineering and Banking Laboratory, National Centre for Cell Science; Kanitkar M, Gokhale K, Galande S, Bhonde RR. Diakses tanggal 2010-06-30.
- ^ (Inggris)"Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation". Diabetes Institute for Immunology and Transplantation, University of Minnesota; Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S. Diakses tanggal 2010-06-30.
- ^ (Inggris)"[The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin]". Department of Public Health, Xi'an Jiaotong University School of Medicine; Yu Y, Hu SK, Yan H. Diakses tanggal 2010-06-30.
- ^ (Inggris)"Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration". Department of Human Morphology and Applied Biology. Faculty of Medicine and Surgery, University of Pisa; Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruffoli R. Diakses tanggal 2010-06-30.
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