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SHANK1

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Revisi sejak 15 Februari 2018 11.05 oleh HsfBot (bicara | kontrib) (Bot: Perubahan kosmetika)
SHANK1
Pengidentifikasi
AliasSHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
ID eksternalOMIM: 604999 MGI: 3613677 HomoloGene: 22949 GeneCards: SHANK1
Ortolog
SpesiesManusiaTikus
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016148

NM_001034115

RefSeq (protein)

NP_057232

NP_001029287

Lokasi (UCSC)n/aChr 7: 43.96 – 44.01 Mb
Pencarian PubMed[2][3]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

SH3 dan beberapa ankyrin ulangi domain protein 1 adalah protein yang pada manusia dikodekan oleh gen SHANK1.[4][5]

Interaksi

SHANK1 telah diketahui berinteraksi dengan:

  • ARHGEF7,[6]
  • BAIAP2,[7]
  • DNM2,[8]
  • SPTAN1,[9] dan
  • Reseptor Somatostatin 2.

Referensi

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038738 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867. 
  5. ^ "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1". 
  6. ^ Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503. 
  7. ^ Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591. 
  8. ^ Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172alt=Dapat diakses gratis. PMID 11583995. 
  9. ^ Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555.