ADCY10

ADCY10
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 4CLK, 4CLL, 4CLP, 4CLS, 4CLT, 4CLU, 4CLW, 4CLY, 4CLZ, 4CM0, 4CM2, 4OYA, 4OYB, 4OYI, 4OYM, 4OYO, 4OYP, 4OYW, 4OYX, 4OYZ, 4OZ2, 4OZ3, 4UST, 4USU, 4USV, 4USW, 5D0R
Pengidentifikasi
Alias	ADCY10, HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble), adenylate cyclase 10, soluble, adenylate cyclase 10
ID eksternal	OMIM: 605205 MGI: 2660854 HomoloGene: 10188 GeneCards: ADCY10
Lokasi gen (Tikus) Kr. Kromosom 1 (tikus) Pita 1|1 H2.3 Awal 165,312,752 bp Akhir 165,404,343 bp
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • nucleotide binding • manganese ion binding • metal ion binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • bicarbonate binding • ATP binding • magnesium ion binding • ATPase binding Komponen seluler • sitoplasma • sitosol • cell projection • membran • microtubule cytoskeleton • growth cone • basal part of cell • Membran sel • apical part of cell • Silia • Akson • soma • Dendrit • mitokondria • perinuclear region of cytoplasm • motile cilium • Sitoskeleton • Inti sel • membran plasma apikal • extracellular region Proses biologis • cellular response to inorganic substance • GO:0007243 intracellular signal transduction • epithelial cilium movement involved in extracellular fluid movement • cyclic nucleotide biosynthetic process • Spermatogenesis • positive regulation of apoptotic process • cAMP biosynthetic process Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	55811	271639
Ensembl	ENSG00000143199	ENSMUSG00000026567
UniProt	Q96PN6	Q8C0T9
RefSeq (mRNA)	NM_001167749 NM_001297772 NM_018417	NM_173029 NM_001357427
RefSeq (protein)	NP_001161221 NP_001284701 NP_060887	NP_766617 NP_001344356
Lokasi (UCSC)	n/a	Chr 1: 165.31 – 165.4 Mb
Pencarian PubMed
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Adenylyl cyclase 10 juga dikenal sebagai ADCY10 adalah enzim yang, pada manusia, dikodekan oleh gen ADCY10.

Fungsi

Protein yang dikodekan oleh gen ini termasuk adenylyl cyclase yang ditemui pada beberapa mamalia. Protein ini larut dan tidak sensitif terhadap regulasi G protein atau forskolin. Protein ini terlokalisasi di sitoplasma dan dianggap berfungsi sebagai sensor bikarbonat umum di seluruh tubuh. Protein ini juga memainkan peran penting dalam pembentukan cAMP di spermatozoa. Sehingga kemungkinan berperan dalam pematangan sperma melalui epididimis, kapasitasi, hipermotilitas, atau reaksi akrosom.

Signifikasi klinis

Mutasi pada gen ADCY10 berhubungan dengan peningkatan risiko adsorpsi hypercalciuria.

Pranala luar

• Lokasi genom ADCY10 manusia dan halaman rincian gen ADCY10 dalam UCSC Genome Browser.

Bacaan lanjutan

• Wuttke MS, Buck J, Levin LR (2002). "Bicarbonate-regulated soluble adenylyl cyclase". JOP. 2 (4 Suppl): 154–8. PMID 11875252. 
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi:10.1074/jbc.273.33.21416 . PMID 9694905. 
• Buck J, Sinclair ML, Schapal L, et al. (1999). "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 79–84. doi:10.1073/pnas.96.1.79. PMC 15096 . PMID 9874775. 
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707 . PMID 10446129. 
• Sinclair ML, Wang XY, Mattia M, et al. (2000). "Specific expression of soluble adenylyl cyclase in male germ cells". Mol. Reprod. Dev. 56 (1): 6–11. doi:10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M. PMID 10737962. 
• Chen Y, Cann MJ, Litvin TN, et al. (2000). "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor". Science. 289 (5479): 625–8. doi:10.1126/science.289.5479.625. PMID 10915626. 
• Jaiswal BS, Conti M (2001). "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase". J. Biol. Chem. 276 (34): 31698–708. doi:10.1074/jbc.M011698200 . PMID 11423534. 
• Reed BY, Gitomer WL, Heller HJ, et al. (2002). "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density". J. Clin. Endocrinol. Metab. 87 (4): 1476–85. doi:10.1210/jc.87.4.1476 . PMID 11932268. 
• Zippin JH, Chen Y, Nahirney P, et al. (2003). "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains". FASEB J. 17 (1): 82–4. doi:10.1096/fj.02-0598fje. PMID 12475901. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• Litvin TN, Kamenetsky M, Zarifyan A, et al. (2003). "Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate". J. Biol. Chem. 278 (18): 15922–6. doi:10.1074/jbc.M212475200 . PMID 12609998. 
• Jaiswal BS, Conti M (2003). "Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10676–81. doi:10.1073/pnas.1831008100. PMC 196863 . PMID 12958208. 
• Marjanovic JA, Li Z, Stojanovic A, Du X (2006). "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation". J. Biol. Chem. 280 (45): 37430–8. doi:10.1074/jbc.M506518200 . PMID 16144836. 
• Schmid A, Sutto Z, Nlend MC, et al. (2007). "Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP". J. Gen. Physiol. 130 (1): 99–109. doi:10.1085/jgp.200709784. PMC 2154360 . PMID 17591988.