Omeprazol
| |
|---|---|
| |
| Nama sistematis (IUPAC) | |
| 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole | |
| Data klinis | |
| Nama dagang | Losec, Prilosec, Zegerid, others[1] |
| AHFS/Drugs.com | monograph |
| Data lisensi | US FDA:link |
| Kat. kehamilan | B3(AU) C(US) |
| Status hukum | Harus dengan resep dokter (S4) (AU) GSL (UK) OTC (US) |
| Rute | Oral, IV |
| Data farmakokinetik | |
| Bioavailabilitas | 35–76%[2][3] |
| Ikatan protein | 95% |
| Metabolisme | Hepatic (CYP2C19, CYP3A4) |
| Waktu paruh | 1–1.2 hours |
| Ekskresi | 80% (urine) 20% (feces) |
| Pengenal | |
| Nomor CAS | 73590-58-6 
|
| Kode ATC | A02BC01 |
| PubChem | CID 4594 |
| Ligan IUPHAR | 4279 |
| DrugBank | DB00338 |
| ChemSpider | 4433
|
| UNII | KG60484QX9
|
| KEGG | D00455
|
| ChEBI | CHEBI:7772
|
| ChEMBL | CHEMBL1503
|
| Data kimia | |
| Rumus | C17H19N3O3S |
| Massa mol. | 345.42 g/mol |
| SMILES | eMolecules & PubChem |
| |
| Data fisik | |
| Titik lebur | 156 °C (313 °F) |
Omeprazol adalah obat yang digunakan dalam pengobatan penyakit refluks gastroesofagus, ulkus peptikum, dan sindrom Zollinger-Ellison.[1] Obat ini juga digunakan untuk mencegah perdarahan saluran cerna atas pada orang yang berisiko tinggi.[1] Obat dapat diminum atau disuntikkan ke pembuluh darah.[1][4]
Referensi
- ^ a b c d "Omeprazole". The American Society of Health-System Pharmacists. Diakses tanggal Dec 1, 2015.
- ^ Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.
- ^ Vaz-Da-Silva, M; Loureiro, AI; Nunes, T; Maia, J; Tavares, S; Falcão, A; Silveira, P; Almeida, L; Soares-Da-Silva, P (2005). "Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions". Clinical Drug Investigation. 25 (6): 391–9. doi:10.2165/00044011-200525060-00004. PMID 17532679.
- ^ "Omeprazole 40 mg Powder for Solution for Infusion". EMC. 10 Feb 2016. Diakses tanggal 29 March 2016.