Triazavirin

Triazavirin
Nama sistematis (IUPAC)
	2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4H)-one
Data klinis
Kat. kehamilan	?
Status hukum	? (US)
Pengenal
Nomor CAS	928659-17-0
Kode ATC	?
PubChem	CID 3113817
ChemSpider	2367718
Data kimia
Rumus	C5H4N6O3S
Massa mol.	228.189
SMILES	eMolecules & PubChem
	InChI InChI=1S/C5H4N6O3S/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5/h1H3,(H,6,8,9); Key:IDVQGNMSSHPZSJ-UHFFFAOYSA-N;

Triazavirin (TZV, Riamilovir) adalah antivirus analog nukleotida yang awalnya dikembangkan di Rusia yang telah menunjukkan kemanjuran terhadap influenza A dan B, termasuk strain H5N1.^[1]^[2]^[3]^[4] Menurut riset, Triazavirin nampaknya mampu mengurangi dampak dari penyakit flu dan juga komplikasi penyakit terkait.^[5] Antivirus ini memiliki inti dari novel triazolotriazine, yang mewakili kelas struktural baru dari obat-obatan antivirus non-nukleosida.^[6]

Referensi

^ Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.
^ Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869 . PMID 16115318.
^ Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629 . PMID 20194696.
^ Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.
^ "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.
^ Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.

[1] Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.

[2] Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869 . PMID 16115318.

[3] Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629 . PMID 20194696.

[4] Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.

[5] "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.

[6] Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.

[1]

[2]

[3]

[4]

[5]

[6]