Aktivin dan inhibin

inhibin, beta A
inhibin, beta A
	The Activin dimer, from 2ARV.pdb
Pengidentifikasi
Simbol	INHBA
Simbol alternatif	activin A
Gen NCBI	3624
HGNC	6066
OMIM	147290
RefSeq	NM_002192
UniProt	P08476
Data lain
Lokus	Chr. 7 p15-p13
Struktur
Pencarian
Struktur	Swiss-model
Domain	InterPro

Pencarian
Struktur	Swiss-model
Domain	InterPro

inhibin, alpha
inhibin, alpha
Pengidentifikasi
Simbol	INHA
Gen NCBI	3623
HGNC	6065
OMIM	147380
RefSeq	NM_002191
UniProt	P05111
Data lain
Lokus	Chr. 2 q33-qter
Struktur
Pencarian
Struktur	Swiss-model
Domain	InterPro

Versi yang bisa dicetak tidak lagi didukung dan mungkin memiliki kesalahan tampilan. Tolong perbarui markah penjelajah Anda dan gunakan fungsi cetak penjelajah yang baku.

inhibin, beta B

Pengidentifikasi

Simbol

INHBB

Simbol alternatif

activin B

Data lain

Chr. 2 cen-q13

Pencarian
Struktur	Swiss-model
Domain	InterPro

inhibin, beta C

Pengidentifikasi

Simbol

INHBC

Simbol alternatif

activin C

Data lain

Chr. 12 q13

Pencarian
Struktur	Swiss-model
Domain	InterPro

inhibin, beta E

Pengidentifikasi

Simbol

INHBE

Simbol alternatif

activin E

Data lain

Chr. 12 q13.2

Pencarian
Struktur	Swiss-model
Domain	InterPro

Aktivin dan inhibin adalah dua kompleks protein yang sangat berkaitan yang nyaris memiliki dampak bioologi yang berlawanan secara langsung. Diidentifikasikan pada 1986,^[1]^[2] aktivin meningkatkan biosintesis dan sekresi FSH, dan berpartisipasi dalam regulasi siklus mesntrual. Beberapa fungsi lainnya yang ditimbulkan oleh aktivin, meliputi peran dalam proliferasi sel, diferensiasi, apoptosis,^[3] metabolisme, homeostasis, respon kekebalahan, perbaikan luka,^[4] dan fungsi endokrin. Sebagliknya, inhibin mengurangi sintesis FSH dan menghambat sekresi FSH.^[5] Peberadaan inhibin dihipotesisasikan pada awal 1916. Namun, keberadaannya belum dinyatakan sampai dinyatakan ada oleh Neena Schwartz dan Cornelia Channing pada pertengahan 1970an, setelah kedua protein tersebut dikarakterisasikan secara molekuler pada sepuluh tahun kemudian.^[6]

Referensi

^ Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J (1986). "Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid". Nature. 321 (6072): 776–9. Bibcode:1986Natur.321..776V. doi:10.1038/321776a0. PMID 3012369.
^ Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986). "Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin". Nature. 321 (6072): 779–82. Bibcode:1986Natur.321..779L. doi:10.1038/321779a0. PMID 3086749.
^ Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY (May 2006). "Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis". Experimental Biology and Medicine. 231 (5): 534–44. doi:10.1177/153537020623100507. PMID 16636301.
^ Sulyok S, Wankell M, Alzheimer C, Werner S (October 2004). "Activin: an important regulator of wound repair, fibrosis, and neuroprotection". Molecular and Cellular Endocrinology. 225 (1–2): 127–32. doi:10.1016/j.mce.2004.07.011. PMID 15451577.
^ van Zonneveld P, Scheffer GJ, Broekmans FJ, Blankenstein MA, de Jong FH, Looman CW, Habbema JD, te Velde ER (March 2003). "Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women". Human Reproduction. 18 (3): 495–501. doi:10.1093/humrep/deg138 . PMID 12615813.
^ Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, Mayo KE, Woodruff TK (October 2014). "Inhibin at 90: from discovery to clinical application, a historical review". Endocrine Reviews. 35 (5): 747–94. doi:10.1210/er.2014-1003. PMC 4167436 . PMID 25051334.

Pranala luar

MeSH Activin
MeSH Inhibin
Grusch M, Kreidl E (2008-08-01). "Activin and follistatin in liver biology and hepatocellular carcinoma". SciTopics. Elsevier. Diarsipkan dari versi asli tanggal 9 December 2008. Diakses tanggal 2008-12-24.

[pmid3012369-1] Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J (1986). "Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid". Nature. 321 (6072): 776–9. Bibcode:1986Natur.321..776V. doi:10.1038/321776a0. PMID 3012369.

[pmid3086749-2] Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986). "Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin". Nature. 321 (6072): 779–82. Bibcode:1986Natur.321..779L. doi:10.1038/321779a0. PMID 3086749.

[pmid16636301-3] Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY (May 2006). "Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis". Experimental Biology and Medicine. 231 (5): 534–44. doi:10.1177/153537020623100507. PMID 16636301.

[pmid15451577-4] Sulyok S, Wankell M, Alzheimer C, Werner S (October 2004). "Activin: an important regulator of wound repair, fibrosis, and neuroprotection". Molecular and Cellular Endocrinology. 225 (1–2): 127–32. doi:10.1016/j.mce.2004.07.011. PMID 15451577.

[5] van Zonneveld P, Scheffer GJ, Broekmans FJ, Blankenstein MA, de Jong FH, Looman CW, Habbema JD, te Velde ER (March 2003). "Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women". Human Reproduction. 18 (3): 495–501. doi:10.1093/humrep/deg138 . PMID 12615813.

[6] Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, Mayo KE, Woodruff TK (October 2014). "Inhibin at 90: from discovery to clinical application, a historical review". Endocrine Reviews. 35 (5): 747–94. doi:10.1210/er.2014-1003. PMC 4167436 . PMID 25051334.

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