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Artikel baru tentang topik farmasi yang masih memerlukan tambahan dan pengembangan. Artikel ini merupakan terjemahan wikipedia bahasa Inggris masih perlu ditinjau ulang juga disesuaikan dengan padanan bahasa Indonesia
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'''Trazodone''' adalah obat golongan [[antidepresan]] . <ref name="AHFS2018">{{Cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|archive-date=19 September 2018|access-date=8 January 2018|url-status=live}}</ref> Obat ini bisa digunakan untuk mengatasi [[gangguan depresi mayor]], [[gangguan kecemasan]], [[insomnia]] dan, juga bisa dikombinasikan dengan obat lain untuk mengatasi, ketergantungan alkohol . <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref> <ref name="CFPC2021">{{Cite web|last=Ton|first=Joey|date=15 November 2021|title=#302 Still awake? Trazodone for insomnia|url=https://cfpclearn.ca/tfp302/|website=CFPCLearn|archive-url=https://web.archive.org/web/20230328114109/https://cfpclearn.ca/tfp302/|archive-date=28 March 2023|access-date=14 June 2023|url-status=live}}</ref> Trazodone bisa dikonsumsi secara oral. <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref>
'''Trazodone''' adalah obat golongan [[antidepresan]] . <ref name="AHFS2018">{{Cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|archive-date=19 September 2018|access-date=8 January 2018|url-status=live}}</ref> Obat ini bisa digunakan untuk mengatasi [[gangguan depresi mayor]], [[gangguan kecemasan]], [[insomnia]] dan, juga bisa dikombinasikan dengan obat lain untuk mengatasi, ketergantungan alkohol . <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref> <ref name="CFPC2021">{{Cite web|last=Ton|first=Joey|date=15 November 2021|title=#302 Still awake? Trazodone for insomnia|url=https://cfpclearn.ca/tfp302/|website=CFPCLearn|archive-url=https://web.archive.org/web/20230328114109/https://cfpclearn.ca/tfp302/|archive-date=28 March 2023|access-date=14 June 2023|url-status=live}}</ref> Trazodone bisa dikonsumsi secara oral. <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref>


Kejadian efek samping yang kerap terjadi yakni [[Xerostomia|mulut kering]], rasa ingin pingsan, muntah, dan rasa sakit kepala. <ref name="AHFS2018">{{Cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|archive-date=19 September 2018|access-date=8 January 2018|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/trazodone-hydrochloride.html "Trazodone Hydrochloride"]. </cite></ref> Efek samping yang parah muncul rasa ingin [[bunuh diri]], [[mania]], [[Aritmia]], dan [[Priapisme|Piapisme]] . <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref> Belum diketahui obat ini aman untuk masa [[kehamilan]], dan masa [[menyusui]] . <ref>{{Cite web|title=Trazodone Use During Pregnancy|url=https://www.drugs.com/pregnancy/trazodone.html|website=Drugs.com|archive-url=https://web.archive.org/web/20190810191222/https://www.drugs.com/pregnancy/trazodone.html|archive-date=10 August 2019|access-date=7 January 2018|url-status=live}}</ref> Trazodone merupakan senyawa fenilpiperazin dari kelas antagonis serotonin dan penghambat reuptake (SARI). <ref>{{Cite book|last=Stahl|first=Stephen M.|date=2008|url=https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|title=Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications|publisher=Cambridge University Press|isbn=9780521857024|page=567|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190811032910/https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|archive-date=11 August 2019|url-status=live}}</ref> <ref>{{Cite book|last=Lemke|first=Thomas L.|last2=Williams|first2=David A.|date=2008|url=https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|title=Foye's Principles of Medicinal Chemistry|publisher=Lippincott Williams & Wilkins|isbn=9780781768795|page=586|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190812031919/https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|archive-date=12 August 2019|url-status=live}}</ref> Obat trazodone juga memiliki efek lain yakni rasa menenangkan. <ref name="BNF69">{{Cite book|date=2015|title=British national formulary: BNF 69|publisher=British Medical Association|isbn=9780857111562|edition=69th|pages=257–258}}</ref>
Kejadian efek samping yang kerap terjadi yakni [[Xerostomia|mulut kering]], rasa ingin pingsan, muntah, dan rasa sakit kepala. <ref name="AHFS2018">{{Cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|archive-date=19 September 2018|access-date=8 January 2018|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/trazodone-hydrochloride.html "Trazodone Hydrochloride"]. </cite></ref> Efek samping yang parah muncul rasa ingin [[bunuh diri]], [[mania]], [[Aritmia]], dan [[Priapisme]] . <ref name="AHFS2018">{{cite web|title=Trazodone Hydrochloride|url=https://www.drugs.com/monograph/trazodone-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 January 2018|archive-date=19 September 2018|archive-url=https://web.archive.org/web/20180919174109/https://www.drugs.com/monograph/trazodone-hydrochloride.html|url-status=live}}</ref> Belum diketahui obat ini aman untuk masa [[kehamilan]], dan masa [[menyusui]] . <ref>{{Cite web|title=Trazodone Use During Pregnancy|url=https://www.drugs.com/pregnancy/trazodone.html|website=Drugs.com|archive-url=https://web.archive.org/web/20190810191222/https://www.drugs.com/pregnancy/trazodone.html|archive-date=10 August 2019|access-date=7 January 2018|url-status=live}}</ref> Trazodone merupakan senyawa fenilpiperazin dari kelas antagonis serotonin dan penghambat reuptake (SARI). <ref>{{Cite book|last=Stahl|first=Stephen M.|date=2008|url=https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|title=Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications|publisher=Cambridge University Press|isbn=9780521857024|page=567|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190811032910/https://books.google.ca/books?id=cWbYxSfKN3cC&pg=PA567|archive-date=11 August 2019|url-status=live}}</ref> <ref>{{Cite book|last=Lemke|first=Thomas L.|last2=Williams|first2=David A.|date=2008|url=https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|title=Foye's Principles of Medicinal Chemistry|publisher=Lippincott Williams & Wilkins|isbn=9780781768795|page=586|language=en|access-date=6 August 2020|archive-url=https://web.archive.org/web/20190812031919/https://books.google.ca/books?id=R0W1ErpsQpkC&pg=PA586|archive-date=12 August 2019|url-status=live}}</ref> Obat trazodone juga memiliki efek lain yakni rasa menenangkan. <ref name="BNF69">{{Cite book|date=2015|title=British national formulary: BNF 69|publisher=British Medical Association|isbn=9780857111562|edition=69th|pages=257–258}}</ref>


== Referensi ==
== Referensi ==
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[[Kategori:Obat]]
[[Kategori:Obat]]
[[Kategori:Farmasi]]
[[Kategori:Farmasi]]
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Revisi per 7 Februari 2024 05.26

Nama sistematis (IUPAC)
2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Data klinis
Nama dagang Many brand names worldwide[1]
AHFS/Drugs.com monograph
MedlinePlus a681038
Data lisensi US Daily Med:pranala
Kat. kehamilan C(US)
Status hukum Harus dengan resep dokter (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US)
Kemungkinan
ketergantungan 		None[2]
Rute By mouth (tablets)
Data farmakokinetik
Bioavailabilitas By mouth: 65%[3]
Ikatan protein 89–95%[4]
Metabolisme Liver (CYP3A4)[5]
Waktu paruh Trazodone IR: 7 hours[3]
Trazodone ER: 10 hours[3]
mCPP: 4–8 hours[6]
Ekskresi Urine: 70–75%[3]
Feces: 21%[3]
Pengenal
Kode ATC ?
Sinonim AF-1161
Data kimia
Rumus C19H22ClN5O 
SMILES eMolecules & PubChem

  • InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 YaY
    Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N YaY

Data fisik
Titik lebur 87 °C (189 °F)

Trazodone adalah obat golongan antidepresan . [7] Obat ini bisa digunakan untuk mengatasi gangguan depresi mayor, gangguan kecemasan, insomnia dan, juga bisa dikombinasikan dengan obat lain untuk mengatasi, ketergantungan alkohol . [7] [8] Trazodone bisa dikonsumsi secara oral. [7]

Kejadian efek samping yang kerap terjadi yakni mulut kering, rasa ingin pingsan, muntah, dan rasa sakit kepala. [7] Efek samping yang parah muncul rasa ingin bunuh diri, mania, Aritmia, dan Priapisme . [7] Belum diketahui obat ini aman untuk masa kehamilan, dan masa menyusui . [9] Trazodone merupakan senyawa fenilpiperazin dari kelas antagonis serotonin dan penghambat reuptake (SARI). [10] [11] Obat trazodone juga memiliki efek lain yakni rasa menenangkan. [12]

Referensi

  1. ^ "Trazodone". Drugs.com (dalam bahasa Inggris). Diarsipkan dari versi asli tanggal 16 September 2018. Diakses tanggal 9 February 2019. 
  2. ^ Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically Disabled (dalam bahasa Inggris). CRC Press. hlm. 26. ISBN 9780824744977. Diarsipkan dari versi asli tanggal 1 August 2020. Diakses tanggal 6 August 2020. 
  3. ^ a b c d e Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. [Verifikasi gagal]
  4. ^ "Trazodone". DrugBank. Diarsipkan dari versi asli tanggal 12 July 2017. Diakses tanggal 7 June 2015. 
  5. ^ Lemke, Thomas L.; Williams, David A. (2012). Foye's Principles of Medicinal Chemistry (dalam bahasa Inggris). Lippincott Williams & Wilkins. hlm. 615. ISBN 9781609133450. Diarsipkan dari versi asli tanggal 17 September 2018. Diakses tanggal 6 August 2020. 
  6. ^ Schatzberg AF, Nemeroff CB (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. hlm. 460–. ISBN 978-1-58562-523-9. 
  7. ^ a b c d e "Trazodone Hydrochloride". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 19 September 2018. Diakses tanggal 8 January 2018.  Kesalahan pengutipan: Tanda <ref> tidak sah; nama "AHFS2018" didefinisikan berulang dengan isi berbeda
  8. ^ Ton, Joey (15 November 2021). "#302 Still awake? Trazodone for insomnia". CFPCLearn. Diarsipkan dari versi asli tanggal 28 March 2023. Diakses tanggal 14 June 2023. 
  9. ^ "Trazodone Use During Pregnancy". Drugs.com. Diarsipkan dari versi asli tanggal 10 August 2019. Diakses tanggal 7 January 2018. 
  10. ^ Stahl, Stephen M. (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (dalam bahasa Inggris). Cambridge University Press. hlm. 567. ISBN 9780521857024. Diarsipkan dari versi asli tanggal 11 August 2019. Diakses tanggal 6 August 2020. 
  11. ^ Lemke, Thomas L.; Williams, David A. (2008). Foye's Principles of Medicinal Chemistry (dalam bahasa Inggris). Lippincott Williams & Wilkins. hlm. 586. ISBN 9780781768795. Diarsipkan dari versi asli tanggal 12 August 2019. Diakses tanggal 6 August 2020. 
  12. ^ British national formulary: BNF 69 (edisi ke-69th). British Medical Association. 2015. hlm. 257–258. ISBN 9780857111562. 
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