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* [[Modafinil]] – sebenarnya penghambat pengambilan kembali dopamin selektif ditambah tindakan lainnya<ref name="pmid32447354">{{cite journal | vauthors = Urban AE, Cubała WJ | title = The role of eugeroics in the treatment of affective disorders | journal = Psychiatr Pol | volume = 54 | issue = 1 | pages = 21–33 | date = February 2020 | pmid = 32447354 | doi = 10.12740/PP/OnlineFirst/90687 | url = | doi-access = free }}</ref><ref name="pmid28318897">{{cite journal | vauthors = Kleeblatt J, Betzler F, Kilarski LL, Bschor T, Köhler S | title = Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence | journal = Eur Neuropsychopharmacol | volume = 27 | issue = 5 | pages = 423–441 | date = May 2017 | pmid = 28318897 | doi = 10.1016/j.euroneuro.2017.03.003 | s2cid = 3740987 | url = }}</ref><ref name="pmid31643130">{{cite journal | vauthors = Nunez NA, Singh B, Romo-Nava F, Joseph B, Veldic M, Cuellar-Barboza A, Cabello Arreola A, Vande Voort JL, Croarkin P, Moore KM, Biernacka J, McElroy SL, Frye MA | title = Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials | journal = Bipolar Disord | volume = 22 | issue = 2 | pages = 109–120 | date = March 2020 | pmid = 31643130 | doi = 10.1111/bdi.12859 | url = | doi-access = free }}</ref><ref name="pmid28256707">{{cite journal | vauthors = Szmulewicz AG, Angriman F, Samamé C, Ferraris A, Vigo D, Strejilevich SA | title = Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis | journal = Acta Psychiatr Scand | volume = 135 | issue = 6 | pages = 527–538 | date = June 2017 | pmid = 28256707 | doi = 10.1111/acps.12712 | s2cid = 3712257 | url = }}</ref>
* [[Modafinil]] – sebenarnya penghambat pengambilan kembali dopamin selektif ditambah tindakan lainnya<ref name="pmid32447354">{{cite journal | vauthors = Urban AE, Cubała WJ | title = The role of eugeroics in the treatment of affective disorders | journal = Psychiatr Pol | volume = 54 | issue = 1 | pages = 21–33 | date = February 2020 | pmid = 32447354 | doi = 10.12740/PP/OnlineFirst/90687 | url = | doi-access = free }}</ref><ref name="pmid28318897">{{cite journal | vauthors = Kleeblatt J, Betzler F, Kilarski LL, Bschor T, Köhler S | title = Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence | journal = Eur Neuropsychopharmacol | volume = 27 | issue = 5 | pages = 423–441 | date = May 2017 | pmid = 28318897 | doi = 10.1016/j.euroneuro.2017.03.003 | s2cid = 3740987 | url = }}</ref><ref name="pmid31643130">{{cite journal | vauthors = Nunez NA, Singh B, Romo-Nava F, Joseph B, Veldic M, Cuellar-Barboza A, Cabello Arreola A, Vande Voort JL, Croarkin P, Moore KM, Biernacka J, McElroy SL, Frye MA | title = Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials | journal = Bipolar Disord | volume = 22 | issue = 2 | pages = 109–120 | date = March 2020 | pmid = 31643130 | doi = 10.1111/bdi.12859 | url = | doi-access = free }}</ref><ref name="pmid28256707">{{cite journal | vauthors = Szmulewicz AG, Angriman F, Samamé C, Ferraris A, Vigo D, Strejilevich SA | title = Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis | journal = Acta Psychiatr Scand | volume = 135 | issue = 6 | pages = 527–538 | date = June 2017 | pmid = 28256707 | doi = 10.1111/acps.12712 | s2cid = 3712257 | url = }}</ref>


;Dihentikan/ditarik
Dihentikan/ditarik:
* [[Amineptin]]
* [[Amineptin]]
* [[Nomifensin]]
* [[Nomifensin]]

Revisi per 11 Juli 2024 22.29

Antidepresan
Kelas obat-obatan
225px
Pengenal kelas
PenggunaanGangguan depresi
Kode ATCN06A
Data klinis
Drugs.comDrug Classes
Consumer ReportsBest Buy Drugs
WebMDMedicineNet  RxList
Pranala luar
MeSHD000928
Dalam Wikidata

Antidepresan adalah sebuah obat yang digunakan untuk mengobati gangguan depresi mayor, beberapa gangguan kecemasan, beberapa kondisi nyeri kronis, dan untuk membantu mengelola beberapa kecanduan.[1] Efek samping umum dari antidepresan termasuk mulut kering, penambahan berat badan, pusing, sakit kepala, dan disfungsi seksual.[2][3][4][5][6]

Sebagian besar jenis antidepresan biasanya aman dikonsumsi, tetapi dapat menyebabkan meningkatnya pikiran untuk bunuh diri ketika dikonsumsi oleh anak-anak, remaja, dan dewasa muda. Sindrom penghentian dapat terjadi setelah menghentikan antidepresan yang menyerupai depresi berulang.

Jenis

Berikut merupakan jenis obat antidepresan:

Selective Serotonin Re-uptake Inhibitor (SSRIs)

Dihentikan/ditarik:

Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)

Serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs)

Serotonin modulators and stimulators (SMSs)

Serotonin antagonist and reuptake inhibitors (SARIs)

Dihentikan/ditarik:

Norepinephrine reuptake inhibitors (NRIs)

Hanya di luar label:

Norepinephrine–dopamine reuptake inhibitors (NDRIs)

  • Bupropion – juga merupakan antagonis non-kompetitif reseptor asetilkolin nikotinat[12]

Hanya di luar label:

Dihentikan/ditarik:

Antidepresan trisiklik

Opipramol, tianeptin, dan amineptin (dihentikan) secara kimiawi adalah TCA tetapi secara farmakodinamika atipikal, dan oleh karena itu dikelompokkan di tempat lain.

Dihentikan/ditarik

Antidepresan tetrasiklik

Mianserin, mirtazapin, dan setiptilin juga kadang-kadang digambarkan sebagai antidepresan noradrenergik dan serotonergik spesifik (NaSSA).

Monoamine Oxidase Inhibitors (MAOIs)

Antipsikotik atipikal

Lainnya

Perawatan tambahan

Obat kombinasi

Referensi

  1. ^ Jennings, Leigh (2018). "Chapter 4: Antidepressants". Dalam Grossberg, George T.; Kinsella, Laurence J. Clinical psychopharmacology for neurologists: a practical guide. Springer. hlm. 45–71. doi:10.1007/978-3-319-74604-3_4. ISBN 978-3-319-74602-9. 
  2. ^ Healy D, Noury LJ, Manginb D (May 2018). "Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases". International Journal of Risk & Safety in Medicine. 29 (3): 125–134. doi:10.3233/JRS-180744. PMC 6004900 alt=Dapat diakses gratis. PMID 29733030. 
  3. ^ Bahrick AS (2008). "Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence". The Open Psychology Journal. 1: 42–50. doi:10.2174/1874350100801010042. 
  4. ^ Taylor MJ, Rudkin L, Bullemor-Day P, Lubin J, Chukwujekwu C, Hawton K (May 2013). "Strategies for managing sexual dysfunction induced by antidepressant medication". The Cochrane Database of Systematic Reviews. 5 (5): CD003382. doi:10.1002/14651858.CD003382.pub3. PMID 23728643. 
  5. ^ Kennedy SH, Rizvi S (April 2009). "Sexual dysfunction, depression, and the impact of antidepressants". Journal of Clinical Psychopharmacology. 29 (2): 157–64. doi:10.1097/jcp.0b013e31819c76e9. PMID 19512977. 
  6. ^ Serotonin and noradrenaline reuptake inhibitors (SNRI); selective serotonin reuptake inhibitors (SSRI) – Persistent sexual dysfunction after drug withdrawal (EPITT no 19277), 11 June 20191, EMA/PRAC/265221/2019, Pharmacovigilance Risk Assessment Committee (PRAC)
  7. ^ Tatsumi M, Groshan K, Blakely RD, Richelson E (December 1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters". European Journal of Pharmacology. 340 (2-3): 249–258. doi:10.1016/s0014-2999(97)01393-9. PMID 9537821. 
  8. ^ Fedder D, Patel H, Saadabadi A (March 2023). "Atomoxetine". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 29630286. 
  9. ^ Dell'Osso B, Palazzo MC, Oldani L, Altamura AC (December 2011). "The noradrenergic action in antidepressant treatments: pharmacological and clinical aspects". CNS Neurosci Ther. 17 (6): 723–32. doi:10.1111/j.1755-5949.2010.00217.x. PMC 6493872 alt=Dapat diakses gratis. PMID 21155988. 
  10. ^ Fleurence R, Williamson R, Jing Y, Kim E, Tran QV, Pikalov AS, Thase ME (2009). "A systematic review of augmentation strategies for patients with major depressive disorder". Psychopharmacol Bull. 42 (3): 57–90. PMID 19752841. 
  11. ^ a b Corp SA, Gitlin MJ, Altshuler LL (September 2014). "A review of the use of stimulants and stimulant alternatives in treating bipolar depression and major depressive disorder". J Clin Psychiatry. 75 (9): 1010–8. doi:10.4088/JCP.13r08851. PMID 25295426. 
  12. ^ Arias HR, Santamaría A, Ali SF (2009). "Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion". Int. Rev. Neurobiol. International Review of Neurobiology. 88: 223–55. doi:10.1016/S0074-7742(09)88009-4. ISBN 9780123745040. PMID 19897080. 
  13. ^ Dale E, Bang-Andersen B, Sánchez C (2015). "Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs". Biochem. Pharmacol. 95 (2): 81–97. doi:10.1016/j.bcp.2015.03.011 alt=Dapat diakses gratis. PMID 25813654. 
  14. ^ Challman TD, Lipsky JJ (2000). "Methylphenidate: its pharmacology and uses". Mayo Clin. Proc. 75 (7): 711–21. doi:10.4065/75.7.711 alt=Dapat diakses gratis. PMID 10907387. 
  15. ^ Prommer E (2012). "Methylphenidate: established and expanding roles in symptom management". Am J Hosp Palliat Care. 29 (6): 483–90. doi:10.1177/1049909111427029. PMID 22144657. 
  16. ^ Urban AE, Cubała WJ (February 2020). "The role of eugeroics in the treatment of affective disorders". Psychiatr Pol. 54 (1): 21–33. doi:10.12740/PP/OnlineFirst/90687 alt=Dapat diakses gratis. PMID 32447354. 
  17. ^ Kleeblatt J, Betzler F, Kilarski LL, Bschor T, Köhler S (May 2017). "Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence". Eur Neuropsychopharmacol. 27 (5): 423–441. doi:10.1016/j.euroneuro.2017.03.003. PMID 28318897. 
  18. ^ Nunez NA, Singh B, Romo-Nava F, Joseph B, Veldic M, Cuellar-Barboza A, Cabello Arreola A, Vande Voort JL, Croarkin P, Moore KM, Biernacka J, McElroy SL, Frye MA (March 2020). "Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials". Bipolar Disord. 22 (2): 109–120. doi:10.1111/bdi.12859 alt=Dapat diakses gratis. PMID 31643130. 
  19. ^ Szmulewicz AG, Angriman F, Samamé C, Ferraris A, Vigo D, Strejilevich SA (June 2017). "Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis". Acta Psychiatr Scand. 135 (6): 527–538. doi:10.1111/acps.12712. PMID 28256707. 

Pranala luar

Lihat entri antidepressant di kamus bebas Wiktionary.


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