Kalsitriol: Perbedaan antara revisi

Kalsitriol
Nama sistematis (IUPAC)
	(1R,3S)- 5-[2-[(1R,3aR,7aS)-1- [(2R)-6-hydroxy-6-methyl-heptan-2-yl]- ; 7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-; 4-methylidene-cyclohexane-1,3-diol
Data klinis
Kat. kehamilan	B3 (Au), C (U.S.)
Status hukum	S4 (Au), POM (UK)
Rute	Oral, IV, topical
Data farmakokinetik
Metabolisme	Renal
Waktu paruh	5–8 hours
Ekskresi	Renal
Pengenal
Nomor CAS	32222-06-3
Kode ATC	A11CC04 D05AX03
PubChem	CID 134070
DrugBank	APRD00246
ChemSpider	4941667
UNII	FXC9231JVH
Data kimia
Rumus	C27H44O3
Massa mol.	416.64 g/mol
SMILES	eMolecules & PubChem

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Revisi per 10 Desember 2010 09.22

Kalsitriol (bahasa Inggris: 1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3, 1,25-(OH)₂D₃) adalah hormon pleitrofik yang merupakan bentuk aktif vitamin D setelah proses konversi oleh ginjal,^[1] yang memiliki sifat anti-proliferatif, pro-apoptotik dan pro-diferensiasi terhadap berbagai jenis sel tubuh, dan sifat anti-kanker, seperti kanker prostat dan kanker usus besar,^[2] oleh kapasitas regulasi terhadap metabolisme kalsium dan fosfat,^[3]^[4] serta modulasi sistem kekebalan dan fungsi sistem saraf pusat.^[2]

Rujukan

^ (Inggris)"Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Risk". Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, International Agency for Research on Cancer, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Institute of Public Health, Institute of Carcinogenesis, Cancer Research Centre, Department of Preventive Medicine, Faculty of Medicine, Palacky University, Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Department of Epidemiology, Institute of Occupational Medicine, Ohio State University Medical Center; Sara Karami, Paul Brennan, Philip S. Rosenberg, Marie Navratilova, Dana Mates, David Zaridze, Vladimir Janout, Helena Kollarova, Vladimir Bencko, Vsevolod Matveev, Neonila Szeszenia-Dabrowska, Ivana Holcatova, Meredith Yeager, Stephen Chanock, Idan Menashe, Nathaniel Rothman, Wong-Ho Chow, Paolo Boffetta, dan Lee E. Moore. Diakses tanggal 2010-12-10.
^ ^a ^b (Inggris)"The pleiotropic actions of vitamin D". Department of Physiology, McGill University; Lin R, White JH. Diakses tanggal 2010-12-10.
^ (Inggris)"Vitamin D and cancer: an update of in vitro and in vivo data". Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid; Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A. Diakses tanggal 2010-12-10.
^ (Inggris)"Vitamin D and colon carcinogenesis". UCLA Center for Human Nutrition, University of California at Los Angeles; Harris DM, Go VL. Diakses tanggal 2010-12-10.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] (Inggris)"Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Risk". Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, International Agency for Research on Cancer, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Institute of Public Health, Institute of Carcinogenesis, Cancer Research Centre, Department of Preventive Medicine, Faculty of Medicine, Palacky University, Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Department of Epidemiology, Institute of Occupational Medicine, Ohio State University Medical Center; Sara Karami, Paul Brennan, Philip S. Rosenberg, Marie Navratilova, Dana Mates, David Zaridze, Vladimir Janout, Helena Kollarova, Vladimir Bencko, Vsevolod Matveev, Neonila Szeszenia-Dabrowska, Ivana Holcatova, Meredith Yeager, Stephen Chanock, Idan Menashe, Nathaniel Rothman, Wong-Ho Chow, Paolo Boffetta, dan Lee E. Moore. Diakses tanggal 2010-12-10.

[PM14696037-2] (Inggris)"The pleiotropic actions of vitamin D". Department of Physiology, McGill University; Lin R, White JH. Diakses tanggal 2010-12-10.

[3] (Inggris)"Vitamin D and cancer: an update of in vitro and in vivo data". Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid; Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A. Diakses tanggal 2010-12-10.

[4] (Inggris)"Vitamin D and colon carcinogenesis". UCLA Center for Human Nutrition, University of California at Los Angeles; Harris DM, Go VL. Diakses tanggal 2010-12-10.

[1]

[2]

[3]

[4]

@@ Baris 44: / Baris 44: @@
 | accessdate   = 2010-12-10
 | work         = Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid; Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A.
+}}</ref><ref>{{en}}{{cite web
+| url          = http://www.ncbi.nlm.nih.gov/pubmed/15570055
+| title        = Vitamin D and colon carcinogenesis
+| accessdate   = 2010-12-10
+| work         = UCLA Center for Human Nutrition, University of California at Los Angeles; Harris DM, Go VL.
 }}</ref> serta [[modulasi]] [[sistem kekebalan]] dan fungsi [[sistem saraf pusat]].<ref name="PM14696037" />
 == Rujukan ==