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PTEN Pengidentifikasi Alias PTEN ID eksternal OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN Lokasi gen (Tikus) Kr. Kromosom 19 (tikus)[ 2] Pita 19 C1|19 28.14 cM Awal 32,734,897 bp [ 2] Akhir 32,803,560 bp [ 2]
Ontologi gen Fungsi molekuler • phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • enzyme binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • pengikatan protein identik • hydrolase activity • lipid binding • ubiquitin-specific protease binding • ionotropic glutamate receptor binding • protein tyrosine kinase binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • PDZ domain binding Komponen seluler • sitoplasma • postsynaptic membrane • extracellular region • mitokondria • neuron projection • cytoplasmic side of plasma membrane • Inti sel • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • membran plasma apikal • Membran sel • PML body • nucleoplasm • sitosol • postsynaptic cytosol Proses biologis • multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • Angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • long-term depression • positive regulation of excitatory postsynaptic potential • cell population proliferation • response to ethanol • neuron projection development • respons seluler terhadap hipoksia • negative regulation of cell size • negative regulation of cell population proliferation • prepulse inhibition • regulation of myeloid cell apoptotic process • male mating behavior • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • Ingatan • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • belajar atau mengingat • perilaku sosial • Sinaptogenesis • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of dendritic spine morphogenesis • brain morphogenesis • GO:0033128 negative regulation of protein phosphorylation • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • GO:0016576 protein dephosphorylation • protein stabilization • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • response to glucose • perkembangan sistem saraf • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • metabolisme lipid • GO:0010260 penuaan • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell population proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • Migrasi sel • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • central nervous system neuron axonogenesis • long-term potentiation • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity • protein deubiquitination • negative regulation of epithelial to mesenchymal transition • negative regulation of keratinocyte migration • cellular response to electrical stimulus • negative regulation of wound healing, spreading of epidermal cells • negative regulation of phosphatidylinositol 3-kinase signaling • GO:1901313 positive regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • response to activity • cellular response to insulin stimulus • cellular response to leptin stimulus • positive regulation of neuron differentiation • cellular response to ethanol • negative regulation of potassium ion transmembrane transporter activity • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • negative regulation of signaling receptor activity • negative regulation of protein kinase B signaling • GO:0097285 Apoptosis • negative regulation of cell migration • regulation of protein stability • negative regulation of focal adhesion assembly • negative regulation of vascular associated smooth muscle cell proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of neuron projection development Sumber:Amigo / QuickGO
Ortolog Spesies Manusia Tikus Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lokasi (UCSC) Chr 10: 87.86 – 87.97 Mb Chr 19: 32.73 – 32.8 Mb Pencarian PubMed [ 3] [ 4] Wikidata
PTEN (bahasa Inggris : phosphatase and tensin homolog, PTEN genetik pada kromosom 10 lokus 10q23.3 dengan ekspresietik berupa protein yang berfungsi sebagai enzim dengan nama PI3P . Mutasi genetik PTEN sering ditemukan pada banyak kasus kanker , sehingga gen ini sering disebut sebagai salah satu tumor suppressor .[ 5]
Tidak seperti umumnya protein fosfatase tirosina , protein ekspresi PTEN lebih banyak mengkatalitik reaksi defosforilasi pada substrat fosfoinositida dan melakukan fungsinya sebagai penghambat tumor dengan menekan lintasan AKT /PKB .
