BMI-1

BMI1
Struktur yang tersedia
PDB	Pencarian Human UniProt: PDBe RCSB
Daftar kode id PDB
	2H0D, 3RPG, 4R8P
Pengidentifikasi
Alias	BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
ID eksternal	OMIM: 164831 HomoloGene: 136787 GeneCards: BMI1
Lokasi gen (Manusia)
Kr.	Kromosom 10 (manusia)
Akhir	22,331,484 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• promoter-specific chromatin binding; • RING-like zinc finger domain binding; • metal ion binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • zinc ion binding;
Komponen seluler	• sitoplasma; • ubiquitin ligase complex; • nucleoplasm; • PRC1 complex; • PcG protein complex; • Inti sel; • sitosol; • nuclear body;
Proses biologis	• GO:0009373 regulation of transcription, DNA-templated; • positive regulation of fibroblast proliferation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • segment specification; • negative regulation of gene expression, epigenetic; • positive regulation of ubiquitin-protein transferase activity; • Regulasi gen; • histone H2A-K119 monoubiquitination; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • hematapoises;
	Sumber:Amigo / QuickGO
Ortolog
	648
	n/a
	ENSG00000168283
	n/a
	P35226; Q5T8Z6
	n/a
	NM_005180
	n/a
	NP_001190991; NP_005171
	n/a
	Wikidata
Lihat/Sunting Manusia

BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog) atau "Polycomb complex protein BMI-1" dikenal juga sebagai "polycomb group RING finger protein 4 (PCGF4)" atau "RING finger protein 51 (RNF51)" adalah protein pada manusia yang disandi oleh gen BMI1 (B cell-specific Moloney murine leukemia virus integration site 1).^[3]^[4] BMI1 adalah suatu onkogen polycomb ring finger.

Fungsi[sunting | sunting sumber]

BMI-1 telah dilaporkan sebagai onkogen dengan mengatur p16 dan p19, yang merupakan gen penghambat sel siklus. Bmi1 knockout pada tikus menyebabkan cacat dalam hematopoiesis, pola kerangka, fungsi neurologis, dan perkembangan otak kecil. Baru-baru ini telah dilaporkan BMI-1 secara cepat direkrut ke situs kerusakan DNA dan mampu bertahan selama lebih dari 8 jam. Hilangnya BMI1 menyebabkan radiasi sensitif dan putusnya untai ganda DNA (DNA double-strand breaks) oleh rekombinasi homolog 10.

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168283 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M (October 1993). "Characterization and chromosomal localization of the human proto-oncogene BMI-1". Hum. Mol. Genet. 2 (10): 1597–603. doi:10.1093/hmg/2.10.1597. PMID 8268912.
^ Siddique HR, Saleem M (March 2012). "Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences". Stem Cells. 30 (3): 372–8. doi:10.1002/stem.1035. PMID 22252887.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168283 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8268912-3] Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M (October 1993). "Characterization and chromosomal localization of the human proto-oncogene BMI-1". Hum. Mol. Genet. 2 (10): 1597–603. doi:10.1093/hmg/2.10.1597. PMID 8268912.

[pmid22252887-4] Siddique HR, Saleem M (March 2012). "Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences". Stem Cells. 30 (3): 372–8. doi:10.1002/stem.1035. PMID 22252887.

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