LPXN

LPXN
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1X3H, 4XEF, 4XEK, 4XEV
Pengidentifikasi
Alias	LPXN, LDPL, leupaxin
ID eksternal	OMIM: 605390 MGI: 2147677 HomoloGene: 3536 GeneCards: LPXN
Lokasi gen (Manusia)
Kr.	Kromosom 11 (manusia)
Akhir	58,578,220 bp
Lokasi gen (Tikus)
Kr.	Kromosom 19 (tikus)
Akhir	12,811,171 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• GO:0001948, GO:0016582 Ikatan protein plasma; • GO:0001104 transcription coregulator activity; • metal ion binding;
Komponen seluler	• sitoplasma; • perinuclear region of cytoplasm; • podosome; • Sambungan sel; • Membran sel; • cell projection; • Inti sel; • focal adhesion; • membran; • sitosol; • nuclear speck;
Proses biologis	• negative regulation of B cell receptor signaling pathway; • negative regulation of cell adhesion; • Adhesi sel; • regulation of cell adhesion mediated by integrin; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0072468 signal transduction; • GO:0034622 protein-containing complex assembly; • regulation of nucleic acid-templated transcription;
	Sumber:Amigo / QuickGO
Ortolog
	9404
	107321
	ENSG00000110031
	ENSMUSG00000024696
	O60711
	Q99N69
	NM_001143995; NM_001307951; NM_004811
	NM_134152; NM_001361971
	NP_001137467; NP_001294880; NP_004802
	NP_598913; NP_001348900
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Leupaxin adalah protein yang pada manusia dikodekan oleh gen LPXN.^[5]^[6]

Produk yang dikodekan oleh gen ini lebih sering diekspresikan dalam sel hematopoietik dan paling homolog dengan protein adhesi fokal, paxillin. Ini dapat berfungsi dalam pensinyalan jenis sel khusus melalui penggabungan dengan PYK2, yang merupakan anggota keluarga kinase adhesi fokus. Sebagai substrat untuk tirosin kinase pada sel limfoid, protein ini juga dapat berfungsi, dan diatur oleh aktivitas tirosin kinase.

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110031 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024696 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lipsky BP, Beals CR, Staunton DE (Jun 1998). "Leupaxin is a novel LIM domain protein that forms a complex with PYK2". J Biol Chem. 273 (19): 11709–13. doi:10.1074/jbc.273.19.11709. PMID 9565592.
^ "Entrez Gene: LPXN leupaxin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110031 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024696 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9565592-5] Lipsky BP, Beals CR, Staunton DE (Jun 1998). "Leupaxin is a novel LIM domain protein that forms a complex with PYK2". J Biol Chem. 273 (19): 11709–13. doi:10.1074/jbc.273.19.11709. PMID 9565592.

[entrez-6] "Entrez Gene: LPXN leupaxin".

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