Tiroid peroksidase: Perbedaan antara revisi
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'''Tiroid peroksidase''' ({{lang-en|thyroid iodide peroxidase,<ref name="PM947933">{{en}}{{cite web |
'''Tiroid peroksidase''' ({{lang-en|thyroid iodide peroxidase,<ref name="PM947933">{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/947933 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/947933 |
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| title = Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase |
| title = Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase |
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| accessdate = 2010-06-19 |
| accessdate = 2010-06-19 |
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| work = Nagasaka A, Hidaka H. |
| work = Nagasaka A, Hidaka H. |
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}}</ref> thyroid peroxidase, thyroperoxidase, TPO}}) adalah [[protein]] yang terglikosilasi dan menempel pada membran plasma apisal [[tirosit]],<ref>{{en}}{{cite web |
}}</ref> thyroid peroxidase, iodide peroxidase, thyroperoxidase, TPO, EC 1.11.1.8}}) adalah [[protein]] yang terglikosilasi dan menempel pada membran plasma apisal [[tirosit]],<ref>{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/12869816 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/12869816 |
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| title = Development of studies of TPO gene and its application in nuclear medicine |
| title = Development of studies of TPO gene and its application in nuclear medicine |
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| accessdate = 2010-06-19 |
| accessdate = 2010-06-19 |
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| work = Department of Nuclear Medicine, West China Hospital, Sichuan University; Xing Y, Kuang A |
| work = Department of Nuclear Medicine, West China Hospital, Sichuan University; Xing Y, Kuang A |
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}}</ref> serta merupakan [[enzim]] yang berperan dalam sintesis [[hormon tiroid]]<ref>{{en}}{{cite web |
}}</ref> serta merupakan [[enzim]] yang berperan dalam sintesis [[hormon tiroid]]<ref>{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/16098474 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/16098474 |
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| title = Structural and functional aspects of thyroid peroxidase |
| title = Structural and functional aspects of thyroid peroxidase |
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| accessdate = 2010-06-19 |
| accessdate = 2010-06-19 |
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| work = Faculté de Médecine Timone, Université de la Méditerranée; Ruf J, Carayon P |
| work = Faculté de Médecine Timone, Université de la Méditerranée; Ruf J, Carayon P |
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}}</ref> termasuk [[hormon]] [[tri-iodotironina|T3]], dari residu [[tiroglobulin]],<ref>{{en}}{{cite web |
}}</ref> termasuk [[hormon]] [[tri-iodotironina|T3]], dari residu [[tiroglobulin]],<ref>{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/10446374 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/10446374 |
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| title = Distinct immunological and biochemical properties of thyroid peroxidase purified from human thyroid glands and recombinant protein produced in insect cells |
| title = Distinct immunological and biochemical properties of thyroid peroxidase purified from human thyroid glands and recombinant protein produced in insect cells |
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}}</ref> di bawah stimulasi [[tirotropin|TSH]]. |
}}</ref> di bawah stimulasi [[tirotropin|TSH]]. |
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TPO membentuk [[homodimer]] peka [[tionamida]] yang merupakan autoantigen universal pada [[penyakit Graves]] dan penyakit autoimunitas lain pada [[kelenjar tiroid]]<ref name="PM19669106">{{en}}{{cite web |
TPO membentuk [[homodimer]] peka [[tionamida]] yang merupakan autoantigen universal pada [[penyakit Graves]] dan penyakit autoimunitas lain pada [[kelenjar tiroid]]<ref name="PM19669106">{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/19669106 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/19669106 |
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| title = Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity |
| title = Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity |
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| accessdate = 2010-06-19 |
| accessdate = 2010-06-19 |
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| work = Institute of Human Genetics, Newcastle University; McDonald DO, Pearce SH |
| work = Institute of Human Genetics, Newcastle University; McDonald DO, Pearce SH |
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}}</ref> dengan memicu [[imunoglobulin|autoantibodi]] [[antibodi G|IgG]] dengan daya ikat tinggi.<ref>{{en}}{{cite web |
}}</ref> dengan memicu [[imunoglobulin|autoantibodi]] [[antibodi G|IgG]] dengan daya ikat tinggi.<ref>{{en}} {{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/11129117 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/11129117 |
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| title = Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator |
| title = Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator |
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}}</ref> Pada kasus [[hipertiroidisme]], TPO dihambat oleh ''6-propyl-2-thiouracil'' (PTU) atau ''1-methyl-2-mercaptoimidazole'' (MMI).<ref name="PM947933" /> |
}}</ref> Pada kasus [[hipertiroidisme]], TPO dihambat oleh ''6-propyl-2-thiouracil'' (PTU) atau ''1-methyl-2-mercaptoimidazole'' (MMI).<ref name="PM947933" /> |
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==Rujukan== |
== Rujukan == |
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{{Enzim}} |
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[[Kategori:Enzim]] |
[[Kategori:Enzim|Peroksidase Tiroid]] |
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[[en:Thyroid peroxidase]] |
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Revisi terkini sejak 18 Desember 2022 02.55
Tiroid peroksidase (bahasa Inggris: thyroid iodide peroxidase,[1] thyroid peroxidase, iodide peroxidase, thyroperoxidase, TPO, EC 1.11.1.8) adalah protein yang terglikosilasi dan menempel pada membran plasma apisal tirosit,[2] serta merupakan enzim yang berperan dalam sintesis hormon tiroid[3] termasuk hormon T3, dari residu tiroglobulin,[4] di bawah stimulasi TSH.
TPO membentuk homodimer peka tionamida yang merupakan autoantigen universal pada penyakit Graves dan penyakit autoimunitas lain pada kelenjar tiroid[5] dengan memicu autoantibodi IgG dengan daya ikat tinggi.[6] Pada kasus hipertiroidisme, TPO dihambat oleh 6-propyl-2-thiouracil (PTU) atau 1-methyl-2-mercaptoimidazole (MMI).[1]
Rujukan
[sunting | sunting sumber]- ^ a b (Inggris) "Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase". Nagasaka A, Hidaka H. Diakses tanggal 2010-06-19.
- ^ (Inggris) "Development of studies of TPO gene and its application in nuclear medicine". Department of Nuclear Medicine, West China Hospital, Sichuan University; Xing Y, Kuang A. Diakses tanggal 2010-06-19.
- ^ (Inggris) "Structural and functional aspects of thyroid peroxidase". Faculté de Médecine Timone, Université de la Méditerranée; Ruf J, Carayon P. Diakses tanggal 2010-06-19.
- ^ (Inggris) "Distinct immunological and biochemical properties of thyroid peroxidase purified from human thyroid glands and recombinant protein produced in insect cells". Medical Centre of Postgraduate Education, Ul. Marymoncka 99, 01-813, Warsaw; Gardas A, Sutton BJ, Piotrowska U, Pasieka Z, Barnett PS, Huang G, McGregor AM, Banga JP. Diakses tanggal 2010-06-19.
- ^ (Inggris) "Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity". Institute of Human Genetics, Newcastle University; McDonald DO, Pearce SH. Diakses tanggal 2010-06-19.
- ^ (Inggris) "Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator". Autoimmune Disease Unit, Cedars-Sinai Research Institute and School of Medicine, University of California; McLachlan SM, Rapoport B. Diakses tanggal 2010-06-19.
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