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'''Faktor PTA''' ({{lang-en|plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI}}) adalah [[zimogen]] dari jenis [[serina protease]] yang merupakan prekursor dari [[faktor XIa]], yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma [[tromboplastin]] intrinsik<ref>{{en}}{{cite web
'''Faktor PTA''' ({{lang-en|plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI}}) adalah [[zimogen]] dari jenis [[serina protease]] yang merupakan prekursor dari [[faktor XIa]], yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma [[tromboplastin]] intrinsik<ref>{{en}} {{cite web
| url = http://medical-dictionary.thefreedictionary.com/factor+VI
| url = http://medical-dictionary.thefreedictionary.com/factor+VI
| title = Factors
| title = Factors
| accessdate = 2010-04-29
| accessdate = 2010-04-29
| work = Farlex free dictionary
| work = Farlex free dictionary
| archive-date = 2021-10-18
⚫
}}</ref> saat darah terpapar oleh permukaan asing.<ref>{{en}}{{cite web
| archive-url = https://web.archive.org/web/20211018212340/https://medical-dictionary.thefreedictionary.com/factor+VI
| dead-url = no
⚫
}}</ref> saat darah terpapar oleh permukaan asing.<ref>{{en}} {{cite web
| url = http://www.answers.com/topic/factor-xi
| url = http://www.answers.com/topic/factor-xi
| title = Factor XI
| title = Factor XI
| accessdate = 2010-04-29
| accessdate = 2010-04-29
| work = Answer.com
| work = Answer.com
| archive-date = 2016-03-04
| archive-url = https://web.archive.org/web/20160304205953/http://www.answers.com/topic/factor-xi
| dead-url = no
}}</ref> Pada [[manusia]], FXI terkodikasi dalam [[gen]] F11.<ref name="pmid3636155">{{cite journal | author = Fujikawa K, Chung DW, Hendrickson LE, Davie EW | title = Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein | journal = Biochemistry | volume = 25 | issue = 9 | pages = 2417–24 | year = 1986 | month = May | pmid = 3636155 | doi = 10.1021/bi00357a018| url = | issn = }}</ref><ref name="pmid2827746">{{cite journal | author = Asakai R, Davie EW, Chung DW | title = Organization of the gene for human factor XI | journal = Biochemistry | volume = 26 | issue = 23 | pages = 7221–8 | year = 1987 | month = November | pmid = 2827746 | doi = 10.1021/bi00397a004| url = | issn = }}</ref><ref name="pmid2612218">{{cite journal | author = Kato A, Asakai R, Davie EW, Aoki N | title = Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 52 | issue = 1-2 | pages = 77–8 | year = 1989 | pmid = 2612218 | doi = 10.1159/000132844| url = | issn = }}</ref><ref name="pmid1673289">{{cite journal | author = Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ | title = A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates | journal = Am. J. Hum. Genet. | volume = 48 | issue = 5 | pages = 911–25 | year = 1991 | month = May | pmid = 1673289 | pmc = 1683054 | doi = | url = | issn = }}</ref>
}}</ref> Pada [[manusia]], FXI terkodikasi dalam [[gen]] F11.<ref name="pmid3636155">{{cite journal | author = Fujikawa K, Chung DW, Hendrickson LE, Davie EW | title = Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein | journal = Biochemistry | volume = 25 | issue = 9 | pages = 2417–24 | year = 1986 | month = May | pmid = 3636155 | doi = 10.1021/bi00357a018| url = | issn = }}</ref><ref name="pmid2827746">{{cite journal | author = Asakai R, Davie EW, Chung DW | title = Organization of the gene for human factor XI | journal = Biochemistry | volume = 26 | issue = 23 | pages = 7221–8 | year = 1987 | month = November | pmid = 2827746 | doi = 10.1021/bi00397a004| url = | issn = }}</ref><ref name="pmid2612218">{{cite journal | author = Kato A, Asakai R, Davie EW, Aoki N | title = Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 52 | issue = 1-2 | pages = 77–8 | year = 1989 | pmid = 2612218 | doi = 10.1159/000132844| url = | issn = }}</ref><ref name="pmid1673289">{{cite journal | author = Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ | title = A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates | journal = Am. J. Hum. Genet. | volume = 48 | issue = 5 | pages = 911–25 | year = 1991 | month = May | pmid = 1673289 | pmc = 1683054 | doi = | url = | issn = }}</ref>


FXI disintesis oleh [[hati]] dan disekresi dalam bentuk [[dimer|homo-dimer]] yang tidak aktif<ref name="pmid18441012">{{cite journal | author = Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN | title = Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa | journal = J. Biol. Chem. | volume = 283 | issue = 27 | pages = 18655–64 | year = 2008 | month = July | pmid = 18441012 | doi = 10.1074/jbc.M802275200 | url = | issn = }}</ref> dengan [[waktu paruh]] sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.<ref>{{en}}{{cite web
FXI disintesis oleh [[hati]] dan disekresi dalam bentuk [[dimer|homo-dimer]] yang tidak aktif<ref name="pmid18441012">{{cite journal | author = Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN | title = Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa | journal = J. Biol. Chem. | volume = 283 | issue = 27 | pages = 18655–64 | year = 2008 | month = July | pmid = 18441012 | doi = 10.1074/jbc.M802275200 | url = | issn = }}</ref> dengan [[waktu paruh]] sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.<ref>{{en}} {{cite web
| url = http://emedicine.medscape.com/article/209984-overview
| url = http://emedicine.medscape.com/article/209984-overview
| title = Factor XI Deficiency
| title = Factor XI Deficiency
| accessdate = 2010-04-29
| accessdate = 2010-04-29
| work = Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel.
| work = Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel.
| archive-date = 2019-08-24
| archive-url = https://web.archive.org/web/20190824133848/https://emedicine.medscape.com/article/209984-overview
| dead-url = no
}}</ref>
}}</ref>


Baris 22: Baris 31:


== Pranala luar ==
== Pranala luar ==
* {{en}} [http://peir.path.uab.edu/coag UAB Coagulation Service]. Department of Pathology, UAB Hospital.
* {{en}} [http://peir.path.uab.edu/coag UAB Coagulation Service] {{Webarchive|url=https://web.archive.org/web/20100703044746/http://peir.path.uab.edu/coag/ |date=2010-07-03 }}. Department of Pathology, UAB Hospital.


== Bacaan lanjut ==
== Bacaan lanjut ==
* {{en}}[http://content.nejm.org/cgi/content/full/342/10/696 High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis]. New England Journal of Medicine; Joost C.M. Meijers, Winnie L.H. Tekelenburg, et al.
* {{en}}[http://content.nejm.org/cgi/content/full/342/10/696 High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis] {{Webarchive|url=https://web.archive.org/web/20100305103009/http://content.nejm.org/cgi/content/full/342/10/696 |date=2010-03-05 }}. New England Journal of Medicine; Joost C.M. Meijers, Winnie L.H. Tekelenburg, et al.


{{Darah}}
{{Darah}}
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[[Kategori:Faktor koagulasi]]
[[Kategori:Faktor koagulasi]]
[[Kategori:Enzim]]
[[Kategori:Enzim]]

[[cs:Faktor XI]]
[[de:Plasma Thromboplastin Antecedent]]
[[en:Factor XI]]

Revisi terkini sejak 17 Juli 2023 14.18

Faktor PTA (bahasa Inggris: plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI) adalah zimogen dari jenis serina protease yang merupakan prekursor dari faktor XIa, yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma tromboplastin intrinsik[1] saat darah terpapar oleh permukaan asing.[2] Pada manusia, FXI terkodikasi dalam gen F11.[3][4][5][6]

FXI disintesis oleh hati dan disekresi dalam bentuk homo-dimer yang tidak aktif[7] dengan waktu paruh sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.[8]

Rujukan

[sunting | sunting sumber]
  1. ^ (Inggris) "Factors". Farlex free dictionary. Diarsipkan dari versi asli tanggal 2021-10-18. Diakses tanggal 2010-04-29. 
  2. ^ (Inggris) "Factor XI". Answer.com. Diarsipkan dari versi asli tanggal 2016-03-04. Diakses tanggal 2010-04-29. 
  3. ^ Fujikawa K, Chung DW, Hendrickson LE, Davie EW (1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein". Biochemistry. 25 (9): 2417–24. doi:10.1021/bi00357a018. PMID 3636155. 
  4. ^ Asakai R, Davie EW, Chung DW (1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221–8. doi:10.1021/bi00397a004. PMID 2827746. 
  5. ^ Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenet. Cell Genet. 52 (1-2): 77–8. doi:10.1159/000132844. PMID 2612218. 
  6. ^ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ (1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". Am. J. Hum. Genet. 48 (5): 911–25. PMC 1683054 alt=Dapat diakses gratis. PMID 1673289. 
  7. ^ Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN (2008). "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". J. Biol. Chem. 283 (27): 18655–64. doi:10.1074/jbc.M802275200. PMID 18441012. 
  8. ^ (Inggris) "Factor XI Deficiency". Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel. Diarsipkan dari versi asli tanggal 2019-08-24. Diakses tanggal 2010-04-29. 

Pranala luar

[sunting | sunting sumber]

Bacaan lanjut

[sunting | sunting sumber]
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