Ribosomal s6 kinase

Kinase ribosomal s6 (bahasa Inggris: ribosomal s6 kinase, A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; protein kinase (phosphorylating); protein kinase A; protein kinase CK2; protein kinase p58; protein phosphokinase; protein serine kinase; protein serine-threonine kinase; protein-aspartyl kinase; protein-cysteine kinase; protein-serine kinase; Prp4 protein kinase; Raf kinase; Raf-1; ribosomal protein S6 kinase II; ribosomal S6 protein kinase; serine kinase; serine protein kinase; serine-specific protein kinase; serine(threonine) protein kinase; serine/threonine protein kinase; STK32; T-antigen kinase; threonine-specific protein kinase; twitchin kinase; type-2 casein kinase; βIIPKC; ε PKC; Wee 1-like kinase; Wee-kinase; WEE1Hu, Rsk, EC 2.7.11.1)</ref> pada jenjang reaksi berikutnya: adalah kinase protein yang mempercepat reaksi fosforilasi pada residu serina/treonina dan teraktivasi melalui lintasan MAPK/ERK. Terdapat dua jenis Rsk, p90^rsk atau MAPK-activated protein kinase-1 (MAPKAP-K1) dan p70^rsk atau S6-H1 Kinase atau S6K.

Pada sistem saraf, Rsk diketahui mempercepat fosforilasi pada protein pro-apoptotik BAD pada serina residu 112, baik in vitro maupun in vivo. Fosforilasi ini mencegah apoptosis neuron yang dimediasi oleh BAD. Katalisasi Rsk juga terjadi pada faktor transkripsi CREB pada serina 133. Fosforilasi CREB berfungsi guna kelangsungan hidup sel, dan terhambatnya fosforilasi ini akan menginduksi apoptosis.